On-line measuring system of body substances
First Claim
1. A measuring system for measuring the concentration of substances or analytes in a body fluid or in a body tissue, comprising:
- a microdialysis probe comprising a microdialysis membrane with a liquid permeability between 1×
10−
4 cm/bar×
s to 3×
10−
4 cm/bar×
s, the probe being adapted to be placed in blood or in tissue,a flow through sensor for analysing a fluid having passed said microdialysis probe,a pump for pumping said fluid to and through said microdialysis probe and further to and through said sensor, andtubing connecting said pump to said microdialysis probe and said microdialysis probe to said sensor,said pump effecting a flow rate in said system in the interval 0.2-15 microliters per minute, wherein the sensor comprises a flow channel having a flow resistance or pressure drop adapted to the characteristics of the microdialysis membrane so as to eliminate, or at least substantially reduce, ultra-filtering in the microdialysis membrane, wherein the ultra-filtering is less than 10% in the flow rate interval 0.2-15 microliters per minute for a flow channel with a pressure drop less than about 100 Pa at a flow rate of about 0.5 microliters per minute and with a pressure drop of less than about 1.6 kPa at a flow rate of about 10 microliters per minute.
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Abstract
A measuring system for measuring the concentration of substances or analytes in a body fluid or in a body tissue comprises a microdialysis probe comprising a microdialysis membrane, the probe being adapted to be placed in blood or in tissue, a flow through sensor for analyzing a fluid having passed the microdialysis probe, a pump for pumping the fluid to and through the microdialysis probe and further to and through the sensor, and tubing connecting the pump to the microdialysis probe and the microdialysis probe to the sensor. The pump effects a flow rate in the system in the interval 0.2-15 microliters per minute. The sensor comprises a flow channel having a flow resistance or pressure drop adapted to the characteristics of the microdialysis membrane so as to eliminate, or at least substantially reduce, ultra filtering in the microdialysis membrane.
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Citations
25 Claims
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1. A measuring system for measuring the concentration of substances or analytes in a body fluid or in a body tissue, comprising:
-
a microdialysis probe comprising a microdialysis membrane with a liquid permeability between 1×
10−
4 cm/bar×
s to 3×
10−
4 cm/bar×
s, the probe being adapted to be placed in blood or in tissue,a flow through sensor for analysing a fluid having passed said microdialysis probe, a pump for pumping said fluid to and through said microdialysis probe and further to and through said sensor, and tubing connecting said pump to said microdialysis probe and said microdialysis probe to said sensor, said pump effecting a flow rate in said system in the interval 0.2-15 microliters per minute, wherein the sensor comprises a flow channel having a flow resistance or pressure drop adapted to the characteristics of the microdialysis membrane so as to eliminate, or at least substantially reduce, ultra-filtering in the microdialysis membrane, wherein the ultra-filtering is less than 10% in the flow rate interval 0.2-15 microliters per minute for a flow channel with a pressure drop less than about 100 Pa at a flow rate of about 0.5 microliters per minute and with a pressure drop of less than about 1.6 kPa at a flow rate of about 10 microliters per minute. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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Specification