Apparatus, systems and methods for determining tissue oxygenation

• US 9,420,967 B2
• Filed: 03/19/2014
• Issued: 08/23/2016
• Est. Priority Date: 03/19/2013
• Status: Active Grant

• Current Assignee: Surgisense Corporation
• Original Assignee: Surgisense Corporation
• Inventors: Zand, Jason M., Fischer, Gregory S.
• Primary Examiner(s): Thomson, William
• Assistant Examiner(s): SORIANO, BOBBY GILES
• Application Number:
  US14/220,034
• Publication Number:
  US 20140288386A1
• Time in Patent Office: 888 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61B 17/068 Surgical staplers , e.g. containing multiple staples or clampsstaplers containing only one staple A61B17/10; magazines or containers for staples A61B17/105; for performing anastomosis A61B17/115; staplers in general B25C5/00
• CPC Class Codes: A61B 17/07207 the staples being applied sequentially
• CPC Class Codes: A61B 17/1155 Circular staplers comprising a plurality of staples
• CPC Class Codes: A61B 2017/00057 Light
• CPC Class Codes: A61B 2017/00084 Temperature
• CPC Class Codes: A61B 2017/07257 characterised by its anvil
• CPC Class Codes: A61B 2090/065 for measuring contact or contact pressure
• CPC Class Codes: A61B 2505/05 Surgical care
• CPC Class Codes: A61B 2562/0238 Optical sensor arrangements for performing transmission measurements on body tissue
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/14556 by fluorescence A61B5/14555 takes precedence
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/4836 Diagnosis combined with treatment in closed-loop systems or methods A61B5/0036 takes precedence
• CPC Class Codes: A61B 5/6847 mounted on an invasive device
• CPC Class Codes: A61B 5/6868 Brain
• CPC Class Codes: A61M 5/007 for contrast media

Abstract

A surgical instrument may be configured to sense a light re-emitting probe to resolve tissue oxygenation, the surgical instrument including: an optical emitter configured to excite the light re-emitting probe within an absorption band of the light re-emitting probe; an optical detector configured to receive the re-emitted light from the probe; and a signal processor configured to resolve the tissue oxygenation based on the received light. The surgical instrument can be a surgical stapler anvil or a flexible substrate having a tissue interfacing surface. Further, a monitoring device may be configured to map oxygenation of a tissue containing a light re-emitting probe, the monitoring device including: an optical emitter configured to excite the light re-emitting probe; at least one optical detector configured to receive the re-emitted light from the probe; and a signal processor that is configured to resolve the tissue oxygenation at multiple points to generate an oxygen map.

Claims

1. A monitoring device configured to map oxygenation of a tissue containing an injectable, light re-emitting probe, the monitoring device comprising:

at least one optical emitter that is configured to excite the injectable, light re-emitting probe;

at least one optical detector configured to receive the re-emitted light from the probe;

a signal processor that is configured to resolve the tissue oxygenation at multiple points based on an oxygen-dependent optical response of light emitted by the injectable, light re-emitting probe to generate an oxygen map; and

a temperature sensor that is configured to detect a temperature of the tissue,

wherein the signal processor is configured to receive temperature data from the temperature sensor to calibrate resolving the tissue oxygenation based on the temperature dependence of the oxygen-dependent optical response.

2. The monitoring device according to claim 1, further comprising at least one injector configured to inject a medium into target tissue, the medium containing the light re-emitting probe.

3. The monitoring device according to claim 1, wherein the optical detector is at least one of a CCD array, a CMOS image sensor and a camera.

4. The monitoring device according to claim 1, wherein the monitoring device is an endoscopic instrument.

5. The monitoring device according to claim 1, wherein the monitoring device is ingestible.

6. The monitoring device according to claim 1, wherein the monitoring device is a surgical instrument.

7. The monitoring device according to claim 6, further comprising an applicator configured to provide a target tissue with a medium, the medium containing the light re-emitting probe.

8. The monitoring device according to claim 6, wherein the signal processor is configured to resolve the tissue oxygenation based on a lifetime of the re-emitted light.

9. The monitoring device according to claim 6, wherein the surgical instrument is a surgical stapler anvil.

10. The monitoring device according to claim 7, wherein the applicator is at least one injector that is configured to inject the medium into the target tissue.

11. The monitoring device according to claim 1, further comprising an interrogator instrument that is configured to interrogate the tissue.

12. The monitoring device according to claim 1, wherein the signal processor makes a determination of an operation success based on the resolution of the tissue oxygenation.

13. The monitoring device according to claim 1, further comprising at least one sensor configured to monitor interaction forces of at least one of compression pressure and tissue tension of the tissue.

14. The monitoring device according to claim 1, wherein the probe is a phosphorescent probe that has multiple absorption wavelengths.

15. The monitoring device according to claim 1, wherein the monitoring device is communicatively coupled to a base station.

16. The monitoring device of claim 1, further comprising:

a flexible substrate having a tissue interfacing surface, the tissue interfacing surface containing (1) at least one optical emitter that is configured to excite the light re-emitting probe, and (2) at least one optical detector configured to receive the re-emitted light from the probe; and

a signal processor that is configured to resolve the tissue oxygenation based on the received light.

17. The monitoring device according to claim 16, wherein the flexible substrate is configured to be one or more of:

(1) affixed to skin and (2) affixed to an internal tissue.

18. The monitoring device according to claim 16, wherein the monitoring device is at least partially bioabsorbable.

19. The monitoring device of claim 1, wherein the calibrating is based on calibration parameters of the probe.

20. The monitoring device of claim 19, wherein the calibration parameters of the probe comprise a quenching constant (kq) and a phosphorescence lifetime in an absence of oxygen (τ

0).