Methods and devices for preparing and implanting tissue scaffolds

• US 9,421,082 B2
• Filed: 03/07/2013
• Issued: 08/23/2016
• Est. Priority Date: 03/27/2009
• Status: Active Grant

• Current Assignee: Depuy Mitek LLC (Johnson & Johnson)
• Original Assignee: Depuy Mitek LLC (Johnson & Johnson)
• Inventors: Sengun, Mehmet Z., DiMatteo, Kristian
• Primary Examiner(s): Woo, Julian W
• Assistant Examiner(s): David, Shaun L
• Application Number:
  US13/788,853
• Publication Number:
  US 20130197666A1
• Time in Patent Office: 1,265 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 17/32053 Punch like cutting instruments, e.g. using a cylindrical or oval knife A61B17/326 takes precedence; trepans A61B17/1695; for use on the cornea A61F9/007
• CPC Class Codes: A61B 2017/00738 part of the tool being offset with respect to a main axis, e.g. for better view for the surgeon
• CPC Class Codes: A61B 2017/00969 used for transplantation
• CPC Class Codes: A61B 2017/320052 Guides for cutting instruments by marking A61B2090/395
• CPC Class Codes: A61B 2090/061 for measuring dimensions, e.g. length
• CPC Class Codes: A61B 2090/3904 specially adapted for marking specified tissue
• CPC Class Codes: A61B 2090/3937 Visible markers
• CPC Class Codes: A61B 90/06 Measuring instruments not otherwise provided for
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61F 2/02 Prostheses implantable into the body closure means for urethra or rectum or for artificial body openings therefor A61F2/0004
• CPC Class Codes: A61F 2/30756 Cartilage endoprostheses A61F2/3603 takes precedence
• CPC Class Codes: A61F 2002/30759 Mosaicplasty, i.e. using a plurality of individual cartilage plugs for filling a substantial cartilage defect
• CPC Class Codes: A61F 2002/30766 Scaffolds for cartilage ingrowth and regeneration
• CPC Class Codes: A61L 2430/06 for cartilage reconstruction, e.g. meniscus
• CPC Class Codes: A61L 2430/34 for soft tissue reconstruction
• CPC Class Codes: A61L 27/3641 characterised by the site of application in the body materials for artificial blood vessels A61L27/507; materials for use in artificial skin A61L27/60
• CPC Class Codes: A61L 27/3654 Cartilage, e.g. meniscus

Abstract

Methods and devices are provided for preparing and implanting tissue scaffolds. Various embodiments of scribing tools are provided that are configured to mark one or more predetermined shapes around a defect site in tissue. The shape or shapes marked in tissue can be used to cut a tissue scaffold having a shape that matches the shape or shapes marked in tissue. In one embodiment, the scribing tool used to mark a shape in tissue can also be used to cut the tissue scaffold.

Claims

1. A tissue repair kit, comprising:

a scribing device having first and second handles and having first and second elongate shafts, each of the first and second shafts having a lumen extending therethrough, the first shaft extending from the first handle, and the second shaft extending from the second handle, the second shaft extending through the lumen of the first elongate shaft with a distal end of the second shaft being located outside of the lumen of the first shaft and being aligned with a longitudinal axis of the first elongate shaft, and a scribing element formed on a distal end of the first elongate shaft, the scribing element extending along an axis that is offset from the longitudinal axis of the first elongate shaft, and the scribing element having a distal-most scribing edge that is curved such that rotation of the scribing device about the longitudinal axis of the first elongate shaft is effective to cause the scribing edge to form a circular mark in tissue; and

a biocompatible tissue repair scaffold configured to be implanted in a defect site in tissue.

2. The tissue repair kit of claim 1, wherein the scribing element is configured to form the circular mark in the tissue by cutting through the tissue without significantly cutting bone underlying the tissue.

3. A surgical method, comprising:

advancing a surgical device into a body of a patient to position a distal scribing tip of the device at a defect site in tissue;

rotating the surgical device about a central longitudinal axis of the surgical device such that the distal scribing tip rotates to form a circular mark in tissue around the defect site;

removing the tissue within the circular mark by suctioning the tissue through the surgical device to form a circular cavity in the tissue;

cutting a biocompatible tissue repair scaffold to have a circular shape that corresponds to the circular mark formed in the tissue; and

implanting the biocompatible tissue repair scaffold in the circular cavity in the tissue;

wherein rotating the surgical device comprises rotating an outer member having the distal scribing tip formed thereon relative to an inner member that engages bone underlying the tissue.

4. The method of claim 3, wherein the surgical device is inserted through an opening in tissue, and wherein the circular mark has a diameter that is greater than a diameter of the opening.

5. The method of claim 3, wherein cutting the biocompatible tissue repair scaffold comprises punching the scaffold with a punch having a diameter that corresponds to a diameter of the circular mark formed in the tissue.

6. The method of claim 3, wherein the circular mark has a diameter in the range of about 5 to 40 mm.

7. The method of claim 3, wherein the biocompatible tissue repair scaffold has a viable tissue disposed thereon.

8. The method of claim 3, wherein cutting the biocompatible tissue repair scaffold includes cutting the biocompatible tissue repair scaffold with the surgical device.

9. The method of claim 3, wherein the distal scribing tip rotates to form the circular mark in the tissue around the defect site without forming a mark in bone underlying the tissue.

10. A surgical method, comprising:

rotating a first scribing device about a longitudinal axis of the first scribing device to form a first substantially circular mark in tissue at a defect site;

removing tissue within the first substantially circular mark by suctioning the tissue through the first scribing device;

rotating a second scribing device about a longitudinal axis of the second scribing device to form a second substantially circular mark in the tissue at the defect site, the second substantially circular mark partially overlapping the first substantially circular mark; and

removing tissue within the second substantially circular mark by suctioning the tissue through the second scribing device to remove a defect in the tissue;

wherein rotating the first scribing device comprises rotating a first outer member having a first distal scribing tip formed thereon relative to a first inner member that engages bone underlying the tissue; and

wherein rotating the second scribing device comprises rotating a second outer member having a second distal scribing tip formed thereon relative to a second inner member that engages bone underlying the tissue.

11. The method of claim 10, further comprising forming at least one linear mark in the tissue, the at least one linear mark extending between an outer edge of the first substantially circular mark and an outer edge of the second substantially circular mark.

12. The method of claim 10, further comprising forming first and second linear marks in the tissue, each linear mark being tangent to the first and second substantially circular marks such that the first and second substantially circular marks and the first and second linear marks form an oblong mark in the tissue.

13. The method of claim 10, wherein removing the tissue within the first and second substantially circular marks forms a cavity in the tissue, and the method further comprises implanting a biocompatible tissue repair scaffold in the cavity in the tissue.

14. The method of claim 13, further comprising, prior to implanting the biocompatible tissue repair scaffold, measuring a maximum length of the first and second substantially circular marks formed in the tissue, and cutting the biocompatible tissue repair scaffold to have a size and shape that corresponds to a size and shape of the cavity in the tissue.

15. The method of claim 14, wherein cutting the biocompatible tissue repair scaffold includes cutting the biocompatible tissue repair scaffold with the first scribing device and the second scribing device.

16. The method of claim 10, wherein the first substantially circular mark has a diameter that differs from a diameter of the second substantially circular mark.

17. The method of claim 10, wherein the first substantially circular mark is formed in the tissue and the second substantially circular mark is formed in the tissue without a mark being formed in bone underlying the tissue.