Use of C-glycoside derivatives as pro-desquamating active agents

• US 9,421,157 B2
• Filed: 06/29/2007
• Issued: 08/23/2016
• Est. Priority Date: 07/03/2006
• Status: Active Grant

• Current Assignee: L'Oreal SA
• Original Assignee: L'Oreal SA
• Inventors: Dalko, Maria, Boulle, Christophe, Bernard, Dominique
• Primary Examiner(s): Ghafoorian, Reza
• Application Number:
  US12/306,565
• Publication Number:
  US 20100003236A1
• Time in Patent Office: 3,343 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61K 2800/28 Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
• CPC Class Codes: A61K 2800/88 Two- or multipart kits
• CPC Class Codes: A61K 8/602 Glycosides, e.g. rutin
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 17/12 Keratolytics, e.g. wart or anti-corn preparations
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/008 Preparations for oily skin
• CPC Class Codes: A61Q 5/006 Antidandruff preparations

Abstract

A cosmetic use of at least one C-glycoside derivative in a composition comprising a physiologically acceptable medium, as a cosmetic agent for promoting the desquamation of the skin and/or the scalp and/or for stimulating epidermal renewal.

Claims

1. A cosmetic method for promoting desquamation of the skin and/or the scalp comprising at least the topical administration to the skin and/or the scalp, as a cosmetic agent, of at least one C-glycoside derivative in a composition comprising a physiologically acceptable medium to promote desquamation to thereby treat xerosis, acne, hyperkeratosis, or ichthyosis, wherein the C-glycoside derivative corresponds to the general formula (I) below:

3. The method according to claim 1, in which S represents a monosaccharide chosen from D-glucose, D-xylose, L-fucose, D-galactose and D-maltose.

4. The method according to claim 1, in which X represents a group chosen from —

CO—

, —

CH(OH)— and

—

CH(NH₂)—

.

5. The method according to claim 1, in which the C-glycoside derivative is chosen from:

C-β

-D-xylopyranoside-n-propan-2-one,

C-α

-D-xylopyranoside-n-propan-2-one,

C-β

-D-xylopyranoside-2-hydroxypropane,

C-α

-D-xylopyranoside-2-hydroxypropane,

1-(C-β

-D-fucopyranoside)propan-2-one,

1-(C-α

-D-fucopyranoside)propan-2-one,

1-(C-β

-L-fucopyranoside)propan-2-one,

1-(C-α

-L-fucopyranoside)propan-2-one,

1-(C-β

-D-fucopyranoside)-2-hydroxypropane,

1-(C-α

-D-fucopyranoside)-2-hydroxypropane,

1-(C-β

-L-fucopyranoside)-2-hydroxypropane,

1-(C-α

-L-fucopyranoside)-2-hydroxypropane,

1-(C-β

-D-glucopyranosyl)-2-hydroxylpropane,

1-(C-α

-D-glucopyranosyl)-2-hydroxylpropane,

1-(C-β

-D-galactopyranosyl)-2-hydroxylpropane,

1-(C-α

-D-galactopyranosyl)-2-hydroxylpropane

1-(C-β

-D-fucofuranosyl)propan-2-one,

1-(C-α

-D-fucofuranosyl)propan-2-one

1-(C-β

-L-fucofuranosyl)propan-2-one,

1-(C-α

-L-fucofuranosyl)propan-2-one,

C-β

-D-maltopyranoside-n-propan-2-one,

C-α

-D-maltopyranoside-n-propan-2-one

C-β

-D-maltopyranoside-2-hydroxypropane,

C-α

-D-maltopyranoside-2-hydroxypropane, isomers thereof and mixtures thereof.

6. The method according to claim 1 in which the C-glycoside derivative is chosen from C-β

-D-xylopyranoside-2-hydroxypropane and C-α

-D-xylopyranoside-2-hydroxypropane.

7. The method according to claim 1, in which the C-glycoside derivative is used in combination with at least:

one moisturizing product,

one epidermal or dermal protease effector,

one exogenous protease and/or glycosidase and/or lipase,

one active agent for improving epidermal differentiation, and/or

one anti-seborrhoeic agent.

2. A method for treating signs associated with a desquamation disorder comprising the topical administration to the skin and/or the scalp of at least one C-glycoside derivative to treat the signs associated with the desquamation disorder, wherein the desquamation disorder is selected from the group consisting of xerosis, acne, hyperkeratosis, and ichthyosis, and the C-glycoside derivative corresponds to the general formula (I) below:

8. A cosmetic treatment process for promoting desquamation, comprising at least the topical administration to the skin and/or the scalp of a composition comprising, in a physiologically acceptable medium, at least one C-glycoside derivative to promote desquamation to thereby treat xerosis, acne, hyperkeratosis, or ichthyosis, wherein the C-glycoside derivative corresponds to the general formula (I) below:

9. A method to promote regular desquamation of reconstructed skin comprising at least the topical administration to the reconstructed skin of a composition comprising, in a physiologically acceptable medium, at least one C-glycoside derivative to promote regular desquamation of the reconstructed skin, wherein the C-glycoside derivative corresponds to the general formula (I) below: