Crosslinked fibers and method of making same by extrusion

• US 9,421,296 B2
• Filed: 01/23/2014
• Issued: 08/23/2016
• Est. Priority Date: 02/21/2009
• Status: Active Grant

• Current Assignee: Covidien LP (Medtronic Plc), Sofradim Production
• Original Assignee: Covidien LP (Medtronic Plc), Sofradim Production
• Inventors: Hadba, Ahmad Robert, Ladet, Sebastien
• Primary Examiner(s): JONES JR., ROBERT STOCKTON
• Application Number:
  US14/161,855
• Publication Number:
  US 20140142626A1
• Time in Patent Office: 943 Days
• Field of Search: 264/176.1, 264/177.1, 264/177.13, 264/186, 264/187, 264/178.F, 525/54.2, 525/54.21, 527/312
• US Class Current: 1/1
• CPC Class Codes: A61L 17/00 Materials for surgical sutures or for ligaturing blood vessels surgical adhesives A61L24/00; surgical instruments, devices or methods for suturing or ligaturing A61B17/04, A61B17/12; supports or packages for suture materials A61B17/04; Materials for prostheses or catheters bone cements or surgical adhesives for soft body tissues A61L24/00; shape or structure of prostheses A61F2/00; shape or structure of catheters A61M5/00
• CPC Class Codes: A61L 2400/18 Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: B29C 48/05 Filamentary, e.g. strands
• CPC Class Codes: C08L 83/04 Polysiloxanes
• CPC Class Codes: D01F 2/00 Monocomponent artificial filaments or the like of cellulose or cellulose derivatives; Manufacture thereof
• CPC Class Codes: D01F 4/00 Monocomponent artificial filaments or the like of proteins; Manufacture thereof
• CPC Class Codes: D01F 6/00 Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
• CPC Class Codes: D01F 6/04 from polyolefins
• CPC Class Codes: D01F 6/06 from polypropylene
• CPC Class Codes: D01F 6/30 comprising olefins as the major constituent
• CPC Class Codes: D01F 6/44 from mixtures of polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds as major constituent with other polymers or low-molecular-weight compounds
• CPC Class Codes: D01F 6/60 from polyamides from polyamino acids or polypeptides D01F6/68
• CPC Class Codes: D01F 6/62 from polyesters
• CPC Class Codes: D01F 6/80 from copolyamides
• CPC Class Codes: D01F 6/84 from copolyesters
• CPC Class Codes: D01F 6/88 from mixtures of polycondensation products as major constituent with other polymers or low-molecular-weight compounds
• CPC Class Codes: D01F 9/00 Artificial filaments or the like of other substances; Manufacture thereof; Apparatus specially adapted for the manufacture of carbon filaments

Abstract

The present disclosure relates to a method of forming fibers. First and second precursors, each possessing a core and at least one functional group known to have click reactivity, are mixed. The mixed precursors are then extruded under heat to cross-link during fiber production.

Claims

1. A fiber prepared by:

obtaining a mixture by mixing first and second precursors each possessing a core and at least one functional group known to have click reactivity, for each of the first and second precursors, the core comprises the same synthetic material and the functional group known to have click reactivity is selected from the group consisting of thiol, azide, alkyne, and alkene, groups, wherein the synthetic material is selected from polyethylene terephthalate, ultra-high molecular weight polyethylene, polypropylene, polyamide, and copolymers, block copolymers, homopolymers, blends and combinations thereof; and

extruding said mixture in order to crosslink the first and second precursors without use of chemical crosslinking agent or catalyst to produce a fiber.

2. The fiber of claim 1, wherein the functional group of the first precursor is an azide and the functional group of the second precursor is an alkyne.

3. The fiber of claim 1, wherein the functional group of the first precursor is a thiol and the functional group of the second precursor is an alkene.

4. A fiber prepared by:

obtaining a mixture by mixing first and second precursors each possessing a core and at least one functional group known to have click reactivity, the core of said first and second precursors including collagen and the functional group known to have click reactivity is selected from the group consisting of thiol, azide, alkyne, and alkene groups; and

gel-spinning said mixture in order to crosslink the first and second precursors to produce a fiber, wherein the functional group of the first precursor has click reactivity with the functional group of the second precursor to crosslink the first and second precursors without use of chemical crosslinking agent or catalyst.

5. The fiber of claim 4, wherein the functional group of the first precursor is an azide and the functional group of the second precursor is an alkyne.

6. The fiber of claim 4, wherein the functional group of the first precursor is a thiol and the functional group of the second precursor is an alkene.