Simple coacervates and methods of use thereof
First Claim
1. A method for producing an adhesive in a subject comprising(a) introducing into the subject a simple coacervate comprising a polyelectrolyte, wherein the polyelectrolyte comprises a polyanion or polycation but not a combination thereof, and the polyelectrolyte comprises at least one crosslinking group capable of covalently crosslinking with itself, and (2) a sufficient amount of a complimentary multivalent cation or multivalent anion to produce the simple coacervate;
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Accused Products
Abstract
Described herein is the synthesis of adhesive from simple adhesive coacervates and their uses thereof. The adhesives are produced by (a) preparing a solution comprising (1) a polyelectrolyte, wherein the polyelectrolyte comprises a polyanion or polycation but not a combination thereof, the polyeletrolyte comprises at least one crosslinking group, and (2) a sufficient amount of a complimentary counterion to produce a simple adhesive coacervate; and (b) crosslinking the simple adhesive coacervate to produce the adhesive. The adhesives have numerous medical and non-medical applications.
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Citations
55 Claims
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1. A method for producing an adhesive in a subject comprising
(a) introducing into the subject a simple coacervate comprising a polyelectrolyte, wherein the polyelectrolyte comprises a polyanion or polycation but not a combination thereof, and the polyelectrolyte comprises at least one crosslinking group capable of covalently crosslinking with itself, and (2) a sufficient amount of a complimentary multivalent cation or multivalent anion to produce the simple coacervate; - and
(b) covalently crosslinking the polyelectrolyte in the simple coacervate to produce the adhesive in the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 31, 32)
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30. A method for modifying one or more surface properties of a substrate, the method comprising
(a) applying on the surface of the substrate a simple coacervate comprising a polyelectrolyte, wherein the polyelectrolyte comprises a polyanion or polycation but not a combination thereof, and the polyelectrolyte comprises at least one crosslinking group capable of covalently crosslinking with itself, and (2) a sufficient amount of a complimentary multivalent cation or multivalent anion to produce the simple coacervate; - and
(b) covalently crosslinking the polyelectrolyte in the simple coacervate on the surface of the substrate to modify one or more surface properties of the substrate.
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33. A method for adhering two substrates together, the method comprising
(a) applying on the surface of a first substrate a simple coacervate comprising a polyelectrolyte, wherein the polyelectrolyte comprises a polyanion or polycation but not a combination thereof, and the polyelectrolyte comprises at least one crosslinking group capable of covalently crosslinking with itself, and (2) a sufficient amount of a complimentary multivalent cation or multivalent anion to produce the simple coacervate; -
(b) applying the second substrate to the first substrate, wherein the second substrate is in contact with the simple coacervate; and (c) covalently crosslinking the polyelectrolyte in the simple coacervate on the surface of the substrate to adhere the first substrate to the second substrate.
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- 34. A simple coacervate comprising (1) a polycation comprising one or more guanidinium groups, wherein the polycation comprises at least one crosslinking group capable of covalently crosslinking with itself, and (2) a sufficient amount of multivalent anion to produce the simple coacervate.
- 36. A simple coacervate comprising (1) a polyanion comprising a polyphosphate compound comprising at least one phosphate group pendant to the polymer backbone and/or at least one phosphate group incorporated in the polymer backbone, wherein the polyanion comprises at least one crosslinking group capable of covalently crosslinking with itself, and (2) a sufficient amount of multivalent cation to produce the simple coacervate.
Specification