Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease
First Claim
1. A method of managing a neurological or psychiatric disease state of a patient, the method comprising:
- measuring first signals from an accelerometer mounted in the patient'"'"'s head, wherein measuring said first signals comprises monitoring head movement and position with respect to gravity using the accelerometer;
extracting first parameters from the first signals that are indicative of a first disease state of the patient;
measuring second signals from an acoustic sensor mounted in the patient'"'"'s head, wherein measuring said second signals comprises monitoring respiratory pattern, latency of vocal signals reaching a steady state threshold amplitude level, and frequency of vocal signals;
extracting second parameters from the second signals that are indicative of the first disease state of the patient;
initiating delivery of a first neural modulation signal to the patient using an implanted stimulator when the first and second extracted parameters indicate that a patient status is in the first disease state, the patient status being calculated primarily from the first signals from the accelerometer and the second signals from the acoustic sensor;
automatically monitoring the patient'"'"'s response to the delivered first neural modulation signal; and
initiating delivery of a subsequent second neural modulation signal using the implanted stimulator when the response to the delivered first neural modulation signal indicates that the subsequent second neural modulation signal is needed to transition the patient status to a second disease state.
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Abstract
A neurological control system for modulating activity of any component or structure comprising the entirety or portion of the nervous system, or any structure interfaced thereto, generally referred to herein as a “nervous system component.” The neurological control system generates neural modulation signals delivered to a nervous system component through one or more intracranial (IC) stimulating electrodes in accordance with treatment parameters. Such treatment parameters may be derived from a neural response to previously delivered neural modulation signals sensed by one or more sensors, each configured to sense a particular characteristic indicative of a neurological or psychiatric condition.
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Citations
24 Claims
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1. A method of managing a neurological or psychiatric disease state of a patient, the method comprising:
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measuring first signals from an accelerometer mounted in the patient'"'"'s head, wherein measuring said first signals comprises monitoring head movement and position with respect to gravity using the accelerometer; extracting first parameters from the first signals that are indicative of a first disease state of the patient; measuring second signals from an acoustic sensor mounted in the patient'"'"'s head, wherein measuring said second signals comprises monitoring respiratory pattern, latency of vocal signals reaching a steady state threshold amplitude level, and frequency of vocal signals; extracting second parameters from the second signals that are indicative of the first disease state of the patient; initiating delivery of a first neural modulation signal to the patient using an implanted stimulator when the first and second extracted parameters indicate that a patient status is in the first disease state, the patient status being calculated primarily from the first signals from the accelerometer and the second signals from the acoustic sensor; automatically monitoring the patient'"'"'s response to the delivered first neural modulation signal; and initiating delivery of a subsequent second neural modulation signal using the implanted stimulator when the response to the delivered first neural modulation signal indicates that the subsequent second neural modulation signal is needed to transition the patient status to a second disease state. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method of managing a neurological or psychiatric disease state of a patient, the method comprising:
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measuring first signals from an accelerometer mounted in the patient'"'"'s head, wherein measuring said first signals comprises monitoring head movement and position with respect to gravity using the accelerometer; extracting first parameters from the first signals that are indicative of a first disease state of the patient; measuring second signals from an acoustic sensor mounted in the patient'"'"'s head, wherein measuring said second signals comprises monitoring respiratory pattern, latency of vocal signals reaching a steady state threshold amplitude level, and frequency of vocal signals; extracting second parameters from the second signals that are indicative of the first disease state of the patient; initiating delivery of a first neural modulation signal to the patient using an implanted stimulator when the first signals and the second signals indicate that a patient status is in the first disease state, the patient status being calculated primarily from the first signals from the accelerometer and the second signals from the acoustic sensor; monitoring the patient'"'"'s response to the first neural modulation signal; and initiating delivery of a subsequent second neural modulation signal configured to transition the patient to a second disease state when the patient'"'"'s response to the first neural modulation signal continues to indicate that the patient status is in the first disease state. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21)
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22. A method of managing epilepsy in a patient, the method comprising:
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monitoring high frequency head vibration, muscle vibration, speech production, and respiratory pattern using an acoustic sensor mounted in the patient'"'"'s head; monitoring head movement and position with respect to gravity using an accelerometer mounted in the patient'"'"'s head; initiating delivery of a first neural modulation signal to the patient using an implanted stimulator when the patient'"'"'s neural activity indicates that a patient status is in a disease state, the patient status being calculated primarily from data provided by the accelerometer and the acoustic sensor; automatically monitoring the patient'"'"'s response after delivering the first neural modulation signal; and initiating delivery of a second neural modulation signal to the patient using the implanted stimulator when the monitored response continues to indicate that the patient status is in the disease state. - View Dependent Claims (23, 24)
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Specification