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Production and utilization of a novel anti-cancer drug in therapy

  • US 9,422,559 B2
  • Filed: 08/12/2013
  • Issued: 08/23/2016
  • Est. Priority Date: 06/02/2010
  • Status: Active Grant
First Claim
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1. A method for inducing a gene silencing effect on BMI-1 and then leading to an increase of p16Ink4a or p14Arf tumor suppressor expression in vivo, comprising:

  • delivering a pro-mir-302 capable of being processed into at least one hairpin-like microRNA precursor in a human cell substrate to an amount, wherein said at least one hairpin-like microRNA precursor contains a seed sequence SEQ ID NO;

    3 and said human cell substrate contains at least a cancerous cell type of human liver cancer, and wherein the amount of said hairpin-like microRNA precursor is higher than 200 micrograms per delivery in vivo.

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