Extraction of myocardial contour points

• US 9,424,642 B2
• Filed: 08/27/2014
• Issued: 08/23/2016
• Est. Priority Date: 08/29/2013
• Status: Expired due to Fees

• Current Assignee: Nihon Medi-Physics Company Limited
• Original Assignee: Nihon Medi-Physics Company Limited
• Inventors: Hamada, Kazuo, Kobayashi, Kazunori
• Primary Examiner(s): CHANG, JON CARLTON
• Application Number:
  US14/469,709
• Publication Number:
  US 20150063670A1
• Time in Patent Office: 727 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61B 5/0044 for the heart
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 6/037 Emission tomography
• CPC Class Codes: A61B 6/503 for diagnosis of the heart
• CPC Class Codes: A61B 6/5217 extracting a diagnostic or physiological parameter from medical diagnostic data
• CPC Class Codes: A61B 6/5235 combining images from the same or different ionising radiation imaging techniques, e.g. PET and CT
• CPC Class Codes: G06T 11/008 Specific post-processing after tomographic reconstruction, e.g. voxelisation, metal artifact correction
• CPC Class Codes: G06T 2200/04 involving 3D image data
• CPC Class Codes: G06T 2207/10076 4D tomography; Time-sequential 3D tomography
• CPC Class Codes: G06T 2207/10104 Positron emission tomography [PET]
• CPC Class Codes: G06T 2207/10108 Single photon emission computed tomography [SPECT]
• CPC Class Codes: G06T 2207/30048 Heart; Cardiac
• CPC Class Codes: G06T 7/0012 Biomedical image inspection
• CPC Class Codes: G06T 7/12 Edge-based segmentation
• CPC Class Codes: G16H 50/30 for calculating health indices; for individual health risk assessment

Abstract

One of the preferred embodiments includes: (a) creating a summed 3D nuclear medicine imaging data by summing a plurality of 3D nuclear medicine imaging data pixel by pixel; (b) determining pixels corresponding to myocardial regions in the summed 3D nuclear medicine imaging data; (c) defining a plurality of tracing directions based on the summed 3D nuclear medicine imaging data, and determining a reference myocardial center base point, a reference inner myocardial wall base point and a reference outer myocardial wall base point for each of the tracing directions; (d) determining a phase-specific myocardial center base point for each of the tracing directions for each of the phases; and (e) seeking a difference between the reference myocardial center base point and the phase-specific myocardial center base point, and determining a phase-specific inner myocardial wall base point and a phase-specific outer myocardial wall base point.

Claims

1. A method performed by a computer processing unit executing computer readable instructions, stored in a non-transitory computer-readable memory, comprising:

(a) creating a summed 3D nuclear medicine imaging data by summing a plurality of 3D nuclear medicine imaging data pixel by pixel, wherein each of the plurality of 3D nuclear medicine imaging data is associated with a plurality of different phases of a cardiac cycle;

(b) determining pixels corresponding to myocardial regions in the summed 3D nuclear medicine imaging data;

(c) defining a plurality of tracing directions based on the summed 3D nuclear medicine imaging data, and determining a reference myocardial center base point, a reference inner myocardial wall base point and a reference outer myocardial wall base point for each tracing direction of the plurality of tracing directions;

(d) determining a phase-specific myocardial center base point for each tracing direction of the plurality of tracing directions for each phase of the plurality of different phases based on the corresponding 3D nuclear medicine imaging data; and

(e) determining a difference in position of the reference myocardial center base point and the phase-specific myocardial center base point, and determining a phase-specific inner myocardial wall base point and a phase-specific outer myocardial wall base point by shifting the reference inner myocardial wall base point and the reference outer myocardial wall base point respectively based on the determined difference, for each tracing direction of the plurality of tracing directions for each phase of the plurality of different phases.

2. The method of claim 1, wherein creating a summed 3D nuclear medicine imaging data in said step (a) being performed after applying a position adjustment operation for at least some of said 3D nuclear medicine imaging data.

3. The method of claim 1, wherein said step (c) further comprises:

creating a binary image data by assigning a first value to pixels in the summed 3D nuclear medicine imaging data which are determined as being associated with myocardial regions, and assigning a second value to pixels in the summed 3D nuclear medicine imaging data which are determined as not being associated with myocardial regions; and

determining the reference myocardial center base point, the reference inner myocardial wall base point and the reference outer myocardial wall base point based on said binary image data in each tracing direction of the plurality of tracing directions.

4. The method of claim 1, wherein said plurality of tracing directions defined in said step (c) are defined such that:

for a region located on an apical side, tracing directions are defined as radially and three-dimensionally from a predetermined starting point in a cardiac ventricle;

for a region located on a basal side, tracing directions are also defined as radially and three-dimensionally from a different starting point in a cardiac ventricle; and

for a central myocardial region located between the region located on the apical side and the region located on the basal side, tracing directions are defined as radially and two-dimensionally in a short axial plane.

5. The method of claim 1, wherein said step (d) is performed such that the phase-specific myocardial center base point may be determined based not only on the 3D nuclear medicine imaging data of the corresponding phase, but also on the 3D nuclear medicine imaging data of the neighboring phases.

6. The method of claim 1, wherein an inter-slice correction and/or an intra-slice correction are applied to positions of at least some of the phase-specific myocardial center base points, before determining the phase-specific inner myocardial wall base points and/or the phase-specific outer myocardial wall base points.

7. The method of claim 1, wherein an inter-phase correction is applied to positions of at least some of the phase-specific myocardial center base points, before determining the phase-specific inner myocardial wall base points and phase-specific outer myocardial wall base points.

8. The method of claim 1, wherein an amount of shifting of inner myocardial wall base points is greater than an amount of shifting of outer myocardial wall base points.

9. An apparatus comprising at least one processor and at least one memory including computer program code, wherein the at least one memory and the computer code are configured, with the at least one processor, to cause the apparatus to at least perform the following:

(a) creating a summed 3D nuclear medicine imaging data by summing a plurality of 3D nuclear medicine imaging data pixel by pixel, wherein each of the plurality of 3D nuclear medicine imaging data is associated with a plurality of different phases of a cardiac cycle;

(b) determining pixels corresponding to myocardial regions in the summed 3D nuclear medicine imaging data;

(c) defining a plurality of tracing directions based on the summed 3D nuclear medicine imaging data, and determining a reference myocardial center base point, a reference inner myocardial wall base point and a reference outer myocardial wall base point for each tracing direction of the plurality of tracing directions;

(d) determining a phase-specific myocardial center base point for each tracing direction of the plurality of tracing directions for each phase of the plurality of different phases based on the corresponding 3D nuclear medicine imaging data; and

(e) determining a difference in position of the reference myocardial center base point and the phase-specific myocardial center base point, and determining a phase-specific inner myocardial wall base point and a phase-specific outer myocardial wall base point by shifting the reference inner myocardial wall base point and the reference outer myocardial wall base point respectively based on the determined difference, for each tracing direction of the plurality of tracing directions for each phase of the plurality of different phases.

10. The apparatus of claim 9, wherein creating a summed 3D nuclear medicine imaging data in said step (a) being performed after applying a position adjustment operation for at least some of said 3D nuclear medicine imaging data.

11. The apparatus of claim 9, wherein said step (c) further comprises:

creating a binary image data by assigning a first value to pixels in the summed 3D nuclear medicine imaging data which are determined as being associated with myocardial regions, and assigning a second value to pixels in the summed 3D nuclear medicine imaging data which are determined as not being associated with myocardial regions; and

determining the reference myocardial center base point, the reference inner myocardial wall base point and the reference outer myocardial wall base point based on said binary image data in each tracing direction of the plurality of tracing directions.

12. The apparatus of claim 9, wherein said plurality of tracing directions defined in said step (c) are defined such that:

for a region located on an apical side, tracing directions are defined as radially and three-dimensionally from a predetermined starting point in a cardiac ventricle;

for a region located on a basal side, tracing directions are also defined as radially and three-dimensionally from a different starting point in a cardiac ventricle; and

for a central myocardial region located between the region located on the apical side and the region located on the basal side, tracing directions are defined as radially and two-dimensionally in a short axial plane.

13. The apparatus of claim 9, wherein said step (d) is performed such that the phase-specific myocardial center base point may be determined based not only on the 3D nuclear medicine imaging data of the corresponding phase, but also on the 3D nuclear medicine imaging data of the neighboring phases.

14. The apparatus of claim 9, wherein an inter-slice correction and/or an intra-slice correction are applied to positions of at least some of the phase-specific myocardial center base points, before determining the phase-specific inner myocardial wall base points and/or the phase-specific outer myocardial wall base points.

15. The apparatus of claim 9, wherein an inter-phase correction is applied to positions of at least some of the phase-specific myocardial center base points, before determining the phase-specific inner myocardial wall base points and phase-specific outer myocardial wall base points.

16. The apparatus of claim 9, wherein an amount of shifting of inner myocardial wall base points is greater than an amount of shifting of outer myocardial wall base points.

17. A computer program product embodied on a non-transitory computer-readable medium in which a computer program is stored that, when being executed by a computer, is configured to provide instructions to control or carry out:

(a) creating a summed 3D nuclear medicine imaging data by summing a plurality of 3D nuclear medicine imaging data pixel by pixel, wherein each of the plurality of 3D nuclear medicine imaging data is associated with a plurality of different phases of a cardiac cycle;

(b) determining pixels corresponding to myocardial regions in the summed 3D nuclear medicine imaging data;

(c) defining a plurality of tracing directions based on the summed 3D nuclear medicine imaging data, and determining a reference myocardial center base point, a reference inner myocardial wall base point and a reference outer myocardial wall base point for each tracing direction of the plurality of tracing directions;

(d) determining a phase-specific myocardial center base point for each tracing direction of the plurality of tracing directions for each phase of the plurality of different phases based on the corresponding 3D nuclear medicine imaging data; and

(e) determining a difference in position of the reference myocardial center base point and the phase-specific myocardial center base point, and determining a phase-specific inner myocardial wall base point and a phase-specific outer myocardial wall base point by shifting the reference inner myocardial wall base point and the reference outer myocardial wall base point respectively based on the determined difference, for each tracing direction of the plurality of tracing directions for each phase of the plurality of different phases.

18. The computer program product of claim 17, wherein creating a summed 3D nuclear medicine imaging data in said step (a) being performed after applying a position adjustment operation for at least some of said 3D nuclear medicine imaging data.

19. The computer program product of claim 17, wherein said step (c) further comprises:

creating a binary image data by assigning a first value to pixels in the summed 3D nuclear medicine imaging data which are determined as being associated with myocardial regions, and assigning a second value to pixels in the summed 3D nuclear medicine imaging data which are determined as not being associated with myocardial regions; and

determining the reference myocardial center base point, the reference inner myocardial wall base point and the reference outer myocardial wall base point based on said binary image data in each tracing direction of the plurality of tracing directions.

20. The computer program product of claim 17, wherein said plurality of tracing directions defined in said step (c) are defined such that:

for a region located on an apical side, tracing directions are defined as radially and three-dimensionally from a predetermined starting point in a cardiac ventricle;

for a region located on a basal side, tracing directions are also defined as radially and three-dimensionally from a different starting point in a cardiac ventricle; and

for a central myocardial region located between the region located on the apical side and the region located on the basal side, tracing directions are defined as radially and two-dimensionally in a short axial plane.

21. The computer program product of claim 17, wherein said step (d) is performed such that the phase-specific myocardial center base point may be determined based not only on the 3D nuclear medicine imaging data of the corresponding phase, but also on the 3D nuclear medicine imaging data of the neighboring phases.

22. The computer program product of claim 17, wherein an inter-slice correction and/or an intra-slice correction are applied to positions of at least some of the phase-specific myocardial center base points, before determining the phase-specific inner myocardial wall base points and/or the phase-specific outer myocardial wall base points.

23. The computer program product of claim 17, wherein an inter-phase correction is applied to positions of at least some of the phase-specific myocardial center base points, before determining the phase-specific inner myocardial wall base points and phase-specific outer myocardial wall base points.

24. The computer program product of claim 17, wherein an amount of shifting of inner myocardial wall base points is greater than an amount of shifting of outer myocardial wall base points.