Analyte permeable membrane systems for oxidative and optical stability
First Claim
1. A sensor for in vivo detection of the presence, amount, and/or concentration of an analyte in a medium within a living animal, the sensor comprising:
- a sensor housing;
an indicator element embedded within and/or covering at least a portion of the sensor housing;
a membrane over at least a portion of the indicator element, wherein the membrane is opaque and reduces deterioration of the indicator element by catalyzing degradation of reactive oxygen species (ROS); and
a layer between the indicator element and the membrane, wherein the layer is on the outside of the indicator element and reduces deterioration of the indicator element by catalyzing degradation of ROS.
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Accused Products
Abstract
A sensor that may be used to detect the presence, amount, and/or concentration of an analyte in a medium within an animal. The sensor may include a sensor housing, an indicator element embedded within and/or covering at least a portion of the sensor housing, and a membrane over the indicator element. The membrane may reduce indicator element deterioration by preventing immune cells, such as white blood cells, from contacting the indicator element, substantially prevent transmission of light of at least a specified wavelength or range of wavelengths through the membrane, and/or permit the analyte to pass through to the indicator element. The membrane may be an opaque diffusion membrane. The sensor may include a foil. The foil may block light and/or reduce indicator element deterioration. The membrane may reduce oxidation of the indicator element.
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Citations
26 Claims
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1. A sensor for in vivo detection of the presence, amount, and/or concentration of an analyte in a medium within a living animal, the sensor comprising:
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a sensor housing; an indicator element embedded within and/or covering at least a portion of the sensor housing; a membrane over at least a portion of the indicator element, wherein the membrane is opaque and reduces deterioration of the indicator element by catalyzing degradation of reactive oxygen species (ROS); and a layer between the indicator element and the membrane, wherein the layer is on the outside of the indicator element and reduces deterioration of the indicator element by catalyzing degradation of ROS. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A sensor for in vivo detection of the presence, amount, and/or concentration of an analyte in a medium within a living animal, the sensor comprising:
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a sensor housing; an indicator element embedded within and/or covering at least a portion of the sensor housing; a membrane over at least a portion of the indicator, wherein the membrane has pores configured to substantially prevent white blood cells from passing through the membrane but to permit the analyte and red blood cells to pass through the membrane; and a layer over the membrane, wherein the layer is configured to block (i) external light from reaching the indicator element and (ii) light from the sensor housing that has passed through the indicator element from reaching bodily tissue of the living animal. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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Specification