Analyte permeable membrane systems for oxidative and optical stability
First Claim
1. A sensor for in vivo detection of the presence, amount, and/or concentration of an analyte in a medium within a living animal, the sensor comprising:
- a sensor housing;
an indicator element embedded within and/or covering at least a portion of the sensor housing; and
a porous, opaque diffusion membrane covering at least a portion of the sensor housing and a portion of the indicator element, wherein the diffusion membrane is configured to substantially prevent white blood cells from passing through the diffusion membrane and permit an analyte of interest to pass through the diffusion membrane to the indicator element and to substantially prevent transmission of light of at least a specified wavelength or range of wavelengths through the diffusion membrane;
wherein the diffusion membrane comprises a layer of hydrophilic material and a layer of torturous path material disposed over or under the layer of hydrophilic material, and the torturous path material is configured to provide a longer path through which reactive oxygen species produced by white blood cells would need to travel before reaching the indicator element.
12 Assignments
0 Petitions
Accused Products
Abstract
A sensor that may be used to detect the presence, amount, and/or concentration of an analyte in a medium within an animal. The sensor may include a sensor housing, an indicator element embedded within and/or covering at least a portion of the sensor housing, and a membrane over the indicator element. The membrane may reduce indicator element deterioration by preventing immune cells, such as white blood cells, from contacting the indicator element, substantially prevent transmission of light of at least a specified wavelength or range of wavelengths through the membrane, and/or permit the analyte to pass through to the indicator element. The membrane may be an opaque diffusion membrane. The sensor may include a foil. The foil may block light and/or reduce indicator element deterioration. The membrane may reduce oxidation of the indicator element.
16 Citations
25 Claims
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1. A sensor for in vivo detection of the presence, amount, and/or concentration of an analyte in a medium within a living animal, the sensor comprising:
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a sensor housing; an indicator element embedded within and/or covering at least a portion of the sensor housing; and a porous, opaque diffusion membrane covering at least a portion of the sensor housing and a portion of the indicator element, wherein the diffusion membrane is configured to substantially prevent white blood cells from passing through the diffusion membrane and permit an analyte of interest to pass through the diffusion membrane to the indicator element and to substantially prevent transmission of light of at least a specified wavelength or range of wavelengths through the diffusion membrane; wherein the diffusion membrane comprises a layer of hydrophilic material and a layer of torturous path material disposed over or under the layer of hydrophilic material, and the torturous path material is configured to provide a longer path through which reactive oxygen species produced by white blood cells would need to travel before reaching the indicator element. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A sensor for in vivo detection of the presence, amount, and/or concentration of an analyte in a medium within a living animal, the sensor comprising:
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a sensor housing; an indicator element embedded within and/or covering at least a portion of the sensor housing; and a porous, opaque diffusion membrane covering at least a portion of the sensor housing and a portion of the indicator element, wherein the diffusion membrane is configured to substantially prevent white blood cells from passing through the diffusion membrane and permit an analyte of interest and red blood cells to pass through the diffusion membrane to the indicator element and to substantially prevent transmission of light of at least a specified wavelength or range of wavelengths through the diffusion membrane, and the diffusion membrane comprises an opaque or light absorbing colorant. - View Dependent Claims (25)
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Specification