Glucose-responsive insulin conjugates
First Claim
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1. A method for treating a subject who has diabetes comprising:
- administering to the subject an amount of a composition comprising a conjugate having the formula
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Abstract
Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein the saccharide for at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.
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4 Claims
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1. A method for treating a subject who has diabetes comprising:
administering to the subject an amount of a composition comprising a conjugate having the formula - View Dependent Claims (2, 3, 4)
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