Solubilization agent for solubilizing polyphenols, flavonoids and/or diterpenoid glucosides

• US 9,433,235 B2
• Filed: 01/24/2011
• Issued: 09/06/2016
• Est. Priority Date: 01/22/2010
• Status: Active Grant

• Current Assignee: Symrise AG
• Original Assignee: Symrise AG
• Inventors: Schrader, Dirk, Riess, Thomas, Homner, Cornelia, Sabater-Lntzel, Christopher
• Primary Examiner(s): Olson, Eric
• Assistant Examiner(s): Miller, Dale R
• Application Number:
  US13/574,102
• Publication Number:
  US 20120322750A1
• Time in Patent Office: 2,052 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A23L 2/385 Concentrates of non-alcoholic beverages
• CPC Class Codes: A23L 2/52 Adding ingredients adding preservatives A23L2/44
• CPC Class Codes: A23L 27/80 Emulsions
• CPC Class Codes: A23L 29/10 containing emulsifiers
• CPC Class Codes: A61K 8/34 Alcohols
• CPC Class Codes: A61K 8/345 containing more than one hydroxy group
• CPC Class Codes: A61K 8/375 the alcohol moiety containing more than one hydroxy group
• CPC Class Codes: A61K 8/602 Glycosides, e.g. rutin
• CPC Class Codes: A61K 8/63 Steroids; Derivatives thereof
• CPC Class Codes: A61K 8/73 Polysaccharides
• CPC Class Codes: A61K 8/732 Starch; Amylose; Amylopectin; Derivatives thereof
• CPC Class Codes: A61K 8/9789 Magnoliopsida [dicotyledons]
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/02 for chemically bleaching or whitening the skin
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

Described is a solubilization agent for solubilizing polyphenols, flavonoids and/or diterpenoid glucosides in aqueous liquids, wherein the solubilization agent consists of a mixture of:

• (a) one emulsifying polymer or a mixture of two, three or more emulsifying polymers,
• (b) one saponin or a mixture of two, three or more saponins,
• (c) one partially or fully water-miscible, preferably liquid, solvent or a mixture of partially or fully water-miscible, preferably liquid, solvents, preferably selected from the group consisting of ethanol, propylene glycol (1,2-propanediol), glycerin, triacetin (glycerin triacetate), diacetin (glycerin diacetate) and triethyl citrate,
• and
• (d) water.

The solubilization agent is particularly suitable for sparingly water soluble polyphenols, flavonoids and/or diterpenoid glucosides. The invention also relates to compositions and (food or cosmetic) formulations comprising said solubilization agent. It further relates to a method for producing solubilization agents, compositions and (food or cosmetic) formulations.

Claims

1. A clear composition comprising:

(i) phloretin, hesperetin, homoeriodictyol, rubusoside and/or naringin,

(ii) water,

(iii) propylene glycol,

(iv)(a) gum Arabic, pectin, traganth gum and/or gum Ghatt, and

(iv)(b) a quillaic saponin,

wherein the weight ratio of (iv)(a) to (iv)(b) is from 20;

1 to 1;

2, the composition is free of ethanol, and the composition remains clear without agitation at 25°

C. and 1013 mbar for at least 1 year.

2. The composition according to claim 1, wherein the weight ratio of (iv)(a) to (iv)(b) is from 10:

1 to 1;

2.

3. A clear composition comprising:

(i) phloretin, homoeriodiclyol, rubsoside and/or naringin,

(ii) water,

(iii) propylene glycol,

(iv)(a) gum Arabic, pectin, traganth gum and/or gum Ghatt, and

(iv)(b) a quillaic saponin,

wherein the weight ratio of (iv)(a) to (iv)(b) is from 20;

1 to 1;

2 the composition remains clear without agitation at 25°

C. and 1013 mbar for at least 1 year.

4. The composition according to claim 3, wherein the weight ratio of (iv)(a) to (iv)(b) is from 10:

1 to 1;

2.