Devices, a computer program product and a method for data extraction

• US 9,433,356 B2
• Filed: 06/24/2010
• Issued: 09/06/2016
• Est. Priority Date: 06/26/2009
• Status: Active Grant

• Current Assignee: Gambro Lundia AB (Baxter International Inc.)
• Original Assignee: Gambro Lundia AB (Baxter International Inc.)
• Inventors: Olde, Bo, Solem, Kristian
• Primary Examiner(s): Kahelin, Michael
• Assistant Examiner(s): Alter, Mitchell E
• Application Number:
  US13/380,631
• Publication Number:
  US 20120283581A1
• Time in Patent Office: 2,266 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/02 Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/02125 of pulse wave propagation time
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/0823 Detecting or evaluating cough events
• CPC Class Codes: A61B 5/4094 Diagnosing or monitoring seizure diseases, e.g. epilepsy
• CPC Class Codes: A61B 5/411 Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: A61B 5/4818 Sleep apnoea
• CPC Class Codes: A61M 1/3639 Blood pressure control, pressure transducers specially adapted therefor
• CPC Class Codes: A61M 2205/3331 Pressure; Flow
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2230/06 Heartbeat rate only
• CPC Class Codes: A61M 2230/40 Respiratory characteristics
• CPC Class Codes: A61M 2230/63 Motion, e.g. physical activity

Abstract

A monitoring device receives a measurement signal obtained by a pressure sensor in an extracorporeal fluid system, such as an extracorporeal blood circuit for a dialysis machine which is in contact with a vascular system of a subject via a fluid connection. The monitoring device processes the measurement signal to identify pressure data that represents pulses originating from a first physiological phenomenon in the subject, excluding the heart of the subject. The first physiological phenomenon may be any of reflexes, voluntary muscle contractions, non-voluntary muscle contractions, a breathing system of the subject, an autonomous system of the subject for blood pressure regulation, or an autonomous system of the subject for body temperature regulation. The monitoring device may detect, present, track or predict a disordered condition of the subject using the pressure data, or monitor the integrity of the fluid connection based on the pressure data.

Claims

1. A device for monitoring the integrity of a fluid connection between an extracorporeal fluid system and a vascular system of a subject having a natural breathing system, said system comprising:

a mechanical pulse generator configured to generate a first pulse;

a pressure sensor configured to sense the first pulse and a second pulse originating from the natural breathing system, and output a measurement signal;

a signal processor; and

a memory device storing a plurality of instructions, which when executed by the signal processor, cause the signal processor to;

(i) analyze the measurement signal to isolate the first pulse and the second pulse;

(ii) monitor whether the second pulse remains present in the measurement signal, and

(iii) when the second pulse originating from the natural breathing system is not present in the measurement signal, send a signal causing at least one of;

(a) an alarm device to activate an alarm, (b) a blood pump to stop, or (c) a valve to close.

2. The device of claim 1,

wherein said measurement signal is a time-dependent monitoring signal, and

wherein said memory device further stores instructions which, when executed by the signal processor, cause the signal processor to calculate a parameter value based on signal values within a time window in the time-dependent monitoring signal, the parameter value representing a distribution of the signal values, and monitor the integrity of the fluid connection based at least partly on the parameter value.

3. The device of claim 2 wherein said memory device further stores instructions which, when executed by the signal processor, cause the signal processor to calculate the parameter value by performing at least one of:

calculating the parameter value as a statistical dispersion measure of the signal values within the time window;

matching the signal values within the time window to a predicted temporal signal profile of the second pulse; and

identifying a candidate second pulse in the time-dependent monitoring signal and a corresponding candidate time point, and validating the candidate second pulse based on the candidate time point in relation to timing information indicative of the timing of the second pulses in the time-dependent monitoring signal.

4. The device of claim 1 wherein said measurement signal is a time-dependent monitoring signal, and said memory device further stores instructions which, when executed by the signal processor, cause the signal processor to:

obtain timing information indicative of the timing of the second pulses in the time-dependent monitoring signal;

process the time-dependent monitoring signal based on the timing information;

calculate a parameter value indicative of presence or absence of the second pulses; and

monitor the integrity of the fluid connection based at least partly on the parameter value.

5. The device of claim 1 wherein said signal processor is not configured to process the measurement signal for identification of heart data originating from heart beats of said subject, and monitor the integrity of the fluid connection based on said heart data.

6. The device of claim 1 wherein said memory device further stores instructions which, when executed by the signal processor, cause the signal processor to process the measurement signal to isolate the second pulses originating from the breathing system of said subject from pluses originating from other physiological phenomena.

7. The device of claim 6 wherein said other physiological phenomenon is a repetitive physiological pulse generator.

8. The device of claim 1 wherein said memory device further stores instructions which, when executed by the signal processor, cause the signal processor to filter the measurement signal in the frequency domain.

9. The device of claim 1 wherein said memory device further stores instructions which, when executed by the signal processor, cause the signal processor to perform at least one of:

low-pass filtering the measurement signal to remove frequencies below about 0.5 Hz, and high-pass filtering the measurement signal to remove frequencies above about 3.5 Hz.

10. The device of claim 9 wherein said memory device further stores instructions which, when executed by the signal processor, cause the signal processor to band-pass filter the measurement signal with respect to at least one frequency range included in the group consisting of 0.15 Hz to 0.4 Hz, 0.04 Hz to 0.15 Hz, and 0.001 Hz to 0.1 Hz.