Inflation media for implants

• US 9,433,501 B2
• Filed: 05/18/2011
• Issued: 09/06/2016
• Est. Priority Date: 05/19/2010
• Status: Expired due to Fees

• Current Assignee: Speyside Medical, LLC
• Original Assignee: Direct Flow Medical, Inc.
• Inventors: Perera, Aruna, Greenan, Trevor, Rogers, Larry
• Primary Examiner(s): Kaucher, Mark
• Assistant Examiner(s): Brooks, Kregg
• Application Number:
  US13/110,812
• Publication Number:
  US 20120022629A1
• Time in Patent Office: 1,938 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61B 2017/00243 cardiac
• CPC Class Codes: A61F 2/24 Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
• CPC Class Codes: A61F 2/2418 Scaffolds therefor, e.g. support stents
• CPC Class Codes: A61F 2/2427 Devices for manipulating or deploying heart valves during implantation
• CPC Class Codes: A61F 2/2433 using balloon catheter
• CPC Class Codes: A61F 2/2436 Deployment by retracting a sheath
• CPC Class Codes: A61F 2/2439 Expansion controlled by filaments
• CPC Class Codes: A61F 2210/0085 hardenable in situ, e.g. epoxy resins
• CPC Class Codes: A61F 2220/0008 Fixation appliances for connecting prostheses to the body
• CPC Class Codes: A61F 2220/0016 with sharp anchoring protrusions, e.g. barbs, pins, spikes
• CPC Class Codes: A61F 2250/0003 having an inflatable pocket filled with fluid, e.g. liquid or gas
• CPC Class Codes: A61F 2310/00005 The prosthesis being constructed from a particular material
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61M 2025/0046 Coatings for improving slidability
• CPC Class Codes: A61M 2025/0681 Systems with catheter and outer tubing, e.g. sheath, sleeve or guide tube
• CPC Class Codes: A61M 25/0009 Making of catheters or other medical or surgical tubes
• CPC Class Codes: A61M 25/0023 by the form of the lumen, e.g. cross-section, variable diameter
• CPC Class Codes: A61M 25/005 with embedded materials for reinforcement, e.g. wires, coils, braids
• CPC Class Codes: A61M 25/0054 with regions for increasing flexibility
• CPC Class Codes: B29C 48/11 : comprising two or more partially or fully enclosed cavities, e.g. honeycomb-shaped
• CPC Class Codes: B29L 2031/7542 : Catheters
• CPC Class Codes: C08G 59/5026 : cycloaliphatic
• CPC Class Codes: C08L 63/00 : Compositions of epoxy resins; Compositions of derivatives of epoxy resins
• CPC Class Codes: G01N 2203/0071 : Creep
• CPC Class Codes: G01N 2203/0073 : Fatigue

Abstract

An inflatable implant is disclosed. The inflatable implant comprises at least one inflation channel for forming an inflatable structure of the inflatable implant; and an inflation media disposed within the at least one inflation channel, wherein the inflation media comprises a mixture of an epoxy resin and a hardener, the mixture is configured to gel at about 37° C in less than about 2.5 hours after mixing to form a gelled mixture.

Claims

1. An inflation media comprising:

an epoxy resin comprising a first compound having at least one N,N-bis(oxiran-2-ylmethyl)aniline segment and a second compound having at least two oxirane groups on a backbone of no more than five carbons;

a hardener comprising at least one cycloaliphatic amine; and

wherein a mixture of the epoxy resin and the hardener has an average viscosity of less than about 100 cps at about 37°

C. over the first 10 minutes of formation; and

wherein the first compound is about 40% to about 60% by weight and the second compound is about 40% to about 60% by weight of the epoxy resin.

2. The inflation media of claim 1, wherein the first compound is N,N-diglycidyl-4-glycidyloxyaniline or 4,4′

-methylenebis(N,N-diglycidylaniline).

3. The inflation media of claim 1, wherein the second compound is selected from the group consisting of 1,4-butanediol diglycidyl ether, 1,2-ethanediol diglycidyl ether, polyglycidyl ether, and 1,3-butadiene diepoxide.

4. The inflation media of claim 1, wherein the at least one cycloaliphatic amine is selected from the group consisting of isophorone diamine, 1,3-bis-aminocyclohexane, diamino cyclohexane, n-aminoethylpiperazine, and n-aminopropylpiperazine.

5. The inflation media of claim 1, wherein the hardener comprises isophorone diamine and 1,3-bis-aminocyclohexane.

6. The inflation media of claim 1, wherein the first compound is N,N-diglycidyl-4-glycidyloxyaniline, the second compound is 1,4-butanediol diglycidyl ether, and the hardener comprises isophorone diamine and 1,3-bis-aminocyclohexane.

7. The inflation media of claim 1, wherein the epoxy resin further comprises a third compound having at least one of the following group:

8. The inflation media of claim 7, wherein the third compound is selected from the group consisting of tris(4-hydroxyphenyl)methane triglycidyl ether, bisphenol-A diglycidyl ether, bisphenol-F diglycidyl ether and resorcinol diglycidyl ether.

9. The inflation media of claim 1, wherein the hardener further comprises an aliphatic amine selected from the group consisting of diethylene triamine, tri-ethylene tetraamine and tetraethylenepentamine.

10. The inflation media of claim 9, wherein the cycloaliphatic amine is about 75% to about 100% and the aliphatic amine is about 0% to about 25% by weight of the hardener.

11. The inflation media of claim 1, wherein the hardener further comprises a radio-opaque compound.

12. The inflation media of claim 11, wherein the radio-opaque compound is selected from the group consisting of 3,5-diiodosalicylic acid, 3-iodo-1-propanol, 2,3,5-triiodobenzoic acid, 3,5-diiodobenzoic acid, 4-iodophenol, 2,4,6-triiodophenol, iodo benzoic acid, iodo salicylic acid, iodobenzene and diiodobenzene.

13. The inflation media of claim 1, wherein the hardener further comprises a catalyst.

14. The inflation media of claim 13, where in the catalyst is water, polybenzoic acid or polyphenol.