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Methods and compositions for gene inactivation

  • US 9,434,776 B2
  • Filed: 10/15/2013
  • Issued: 09/06/2016
  • Est. Priority Date: 05/25/2006
  • Status: Active Grant
First Claim
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1. A protein comprising an engineered zinc finger protein DNA-binding domain that binds to an endogenous CCR5 gene, wherein the DNA-binding domain comprises four zinc finger recognition regions ordered F1 to F4 from N-terminus to C-terminus, and further wherein the zinc finger DNA-binding domains comprise recognition regions selected from the group consisting of:

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