Modified FGF-21 polypeptides comprising an internal deletion and uses thereof
First Claim
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1. A modified FGF-21 polypeptide comprising a polypeptide having an amino acid sequence having at least 98% amino acid sequence identity to SEQ ID NO:
- 102.
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Abstract
Modified FGF-21 polypeptides and uses thereof are provided, for example, for the treatment of diseases associated with fibrosis. Modified FGF-21 polypeptides are disclosed that contain an internal deletion and optionally replacement peptide, optionally modified with at least one non-naturally-encoded amino acid, and/or optionally fused to a fusion partner.
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Citations
20 Claims
- 1. A modified FGF-21 polypeptide comprising a polypeptide having an amino acid sequence having at least 98% amino acid sequence identity to SEQ ID NO:
- 14. A modified FGF-21 polypeptide comprising a polypeptide having the amino acid sequence of SEQ ID NO:
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19. A modified FGF-21 polypeptide comprising a polypeptide having the amino acid sequence of SEQ ID NO:
- 202, wherein the para-acetyl-L-phenylalanine in SEQ ID NO;
202 is linked to a poly(ethylene glycol) having an average molecular weight of about 30 kDa. - View Dependent Claims (20)
- 202, wherein the para-acetyl-L-phenylalanine in SEQ ID NO;
Specification