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Adjuvant incorporation in immunoanotherapeutics

  • US 9,439,859 B2
  • Filed: 11/19/2013
  • Issued: 09/13/2016
  • Est. Priority Date: 10/12/2008
  • Status: Active Grant
First Claim
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1. A polymeric particulate composition comprising:

  • nanocarriers formed by self-assembly of a mixture of amphiphilic polymers having a hydrophobic polymer selected from the group consisting of polyanhydrides, polyhydroxy acids, and polyesters at one end and a hydrophilic polymer comprising a polyalkylene oxide at the other end and amphiphilic polymers having at least one moiety bound to the hydrophilic ends of the amphiphilic polymers; and

    an immunostimulatory agent or MHC Class I, MHC Class II or CD1 presentable polypeptide antigen associated with the surface of the nanocarrier;

    as the moiety bound to the hydrophilic end of the polymer, or encapsulated within the nanocarrier.

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