Isolated nucleotide sequences encoding GDF traps
First Claim
Patent Images
1. An isolated nucleic acid comprising a nucleic acid sequence that hybridizes to the complement of nucleotides 76-396 of SEQ ID NO:
- 30 in the presence of 6.0×
sodium chloride/sodium citrate (SSC) at 45°
C. followed by a wash in 0.2×
SSC at 65°
C., wherein the nucleic acid sequence encodes a polypeptide that comprises an acidic amino acid at the position corresponding to position 79 of SEQ ID NO;
1.
1 Assignment
0 Petitions
Accused Products
Abstract
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
197 Citations
15 Claims
-
1. An isolated nucleic acid comprising a nucleic acid sequence that hybridizes to the complement of nucleotides 76-396 of SEQ ID NO:
- 30 in the presence of 6.0×
sodium chloride/sodium citrate (SSC) at 45°
C. followed by a wash in 0.2×
SSC at 65°
C., wherein the nucleic acid sequence encodes a polypeptide that comprises an acidic amino acid at the position corresponding to position 79 of SEQ ID NO;
1. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
- 30 in the presence of 6.0×
Specification