Apparatus and method for controlling insulin infusion with state variable feedback
First Claim
1. An apparatus for infusing insulin into a body of a user, the apparatus comprising:
- a housing;
a pump inside the housing for delivering insulin into the body of the user; and
at least one controller to control delivery of the insulin from the housing by the pump, wherein the at least one controller;
controls delivery of a basal amount of insulin to the body of the user at a predetermined basal rate;
determines at least one state variable, said at least one state variable being at least one of subcutaneous insulin concentration, plasma insulin concentration, and insulin effect;
determines, based on the at least one state variable, an additional amount of insulin to be delivered to the body of the user;
controls delivery of the determined additional amount of insulin to the body of the user; and
reduces the basal rate by the additional amount of insulin.
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Accused Products
Abstract
An infusion system, which may be a closed loop infusion system or “semi-closed-loop” system, uses state variable feedback to control the rate that fluid is infused into the body of a user. The closed loop infusion system includes a sensor system, a controller, and a delivery system. The “semi-closed-loop” system further includes prompts that are displayed or sounded or otherwise provide indications to the user prior to fluid delivery. The sensor system includes a sensor for monitoring a condition of the user. The sensor produces a sensor signal, which is representative of the condition of the user. The delivery system infuses a fluid into the user at a rate dictated by the commands from the controller. The system may use three state variables, subcutaneous insulin concentration, plasma insulin concentration, and insulin effect, and corresponding gains, to calculate an additional amount of fluid to be infused as a bolus and to be removed from the basal delivery of the fluid.
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Citations
8 Claims
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1. An apparatus for infusing insulin into a body of a user, the apparatus comprising:
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a housing; a pump inside the housing for delivering insulin into the body of the user; and at least one controller to control delivery of the insulin from the housing by the pump, wherein the at least one controller; controls delivery of a basal amount of insulin to the body of the user at a predetermined basal rate; determines at least one state variable, said at least one state variable being at least one of subcutaneous insulin concentration, plasma insulin concentration, and insulin effect; determines, based on the at least one state variable, an additional amount of insulin to be delivered to the body of the user; controls delivery of the determined additional amount of insulin to the body of the user; and reduces the basal rate by the additional amount of insulin. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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Specification