Microfabricated neurostimulation device

• US 9,440,082 B2
• Filed: 06/19/2014
• Issued: 09/13/2016
• Est. Priority Date: 11/12/2008
• Status: Active Grant

• Current Assignee: Ecole polytechnique fãdãrale de lausanne epfl (Schweizerische Eidgenossenschaft)
• Original Assignee: Ecole polytechnique fãdãrale de lausanne epfl (Schweizerische Eidgenossenschaft)
• Inventors: Mercanzini, Andre, Renaud, Philippe
• Primary Examiner(s): Flory, Christopher A
• Application Number:
  US14/309,491
• Publication Number:
  US 20140303703A1
• Time in Patent Office: 817 Days
• Field of Search: 607/2, 607/45, 607/116, 600/378, 600/544
• US Class Current: 1/1
• CPC Class Codes: A61B 17/34 Trocars; Puncturing needles pointed biopsy instruments A61B10/0233; devices for piercing the ear-lobes A44C7/001; seals or hemostasis valves A61M39/06
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/388 Nerve conduction study, e.g. detecting action potential of peripheral nerves
• CPC Class Codes: A61B 5/6868 Brain
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula
• CPC Class Codes: Y10T 29/49117 Conductor or circuit manufacturing

Abstract

Described herein are microelectrode array devices, and methods of fabrication and use of the same, to provide highly localized and efficient electrical stimulation of a neurological target. The device includes multiple microelectrode elements arranged along an elongated probe shaft. The microelectrode elements are dimensioned and shaped so as to target individual neurons, groups of neurons, and neural tissue as may be located in an animal nervous system, such as deep within a human brain. Beneficially, the neurological probe can be used to facilitate location of the neurological target and remain implanted for long-term monitoring and/or stimulation.

Claims

1. An implantable neurological device, comprising:

a support tube;

a cylindrical member having a distal end, a proximal end, and an internal lumen; and

a microelectrode film attached to an outer surface of the support tube to form a cylindrical substrate and with the support tube defining a lumen of the cylindrical substrate, the microelectrode film comprising a plurality of microelectrode elements, a longitudinal extension extending from a distal end of the microelectrode film, and a proximal end, the distal end of the microelectrode film disposed toward the distal end of the cylindrical member, a portion of the longitudinal extension extending in the internal lumen of the cylindrical member toward the proximal end of the cylindrical member.

2. The device of claim 1, the microelectrode film comprising:

a first insulative layer;

a plurality of lead contacts;

a plurality of conductive traces to couple the plurality of lead contacts to the plurality of microelectrode elements; and

a second insulative layer disposed on the plurality of conductive traces and the first insulative layer.

3. The device of claim 1, wherein each of the plurality of microelectrode elements are individually addressable.

4. The device of claim 1, comprising:

an electronic component electrically coupled between the plurality of microelectrode elements and a plurality of lead contacts disposed on the longitudinal extension of the microelectrode film.

5. The device of claim 4, comprising:

the electronic component including a router to selectively couple the plurality of microelectrode elements with the plurality of lead contacts disposed on the longitudinal extension of the microelectrode film.

6. The device of claim 1, comprising:

at least one of the plurality of microelectrode elements shaped substantially different from another microelectrode element of the plurality of microelectrode elements.

7. The device of claim 1, the plurality of microelectrode elements comprising at least one circumferential electrode.

8. The device of claim 1, the plurality of microelectrode elements comprising at least one segmented electrode.

9. The device of claim 1, comprising:

the plurality of microelectrode elements configured as a micro-electromechanical system (MEMS).

10. The device of claim 1, comprising:

one or more of the plurality of microelectrode elements including a recording element; and

one or more of the plurality of microelectrode elements including a stimulating element.

11. An implantable neurological device, comprising:

a support tube;

a microelectrode film attached to an outer surface of the support tube to form a cylindrical substrate, the support tube defining a lumen of the cylindrical substrate, the microelectrode film comprising;

one or more microelectrode elements; and

an extension, a portion of the extension extending into the lumen defined by the cylindrical substrate.

12. The device of claim 11, wherein the extension extends from a distal end of the microelectrode film into the lumen defined by the cylindrical substrate.

13. The device of claim 11, wherein the extension extends radially from the microelectrode film into the lumen defined by the cylindrical substrate.

14. The device of claim 11, the microelectrode film comprising:

a first insulative layer;

a plurality of lead contacts;

a plurality of conductive traces to couple the plurality of lead contacts to the one or more microelectrode elements; and

a second insulative layer disposed on the plurality of conductive traces and the first insulative layer.

15. The device of claim 14, comprising:

an electronic component electrically coupled between the one or more microelectrode elements and a plurality of lead contacts.

16. The device of claim 15, comprising:

a router to couple the one or more microelectrode elements with the plurality of lead contacts.

17. The device of claim 11, comprising:

at least one circumferential electrode.

18. The device of claim 11, comprising:

at least one segmented electrode.

19. The device of claim 11, comprising:

one or more microelectrode elements configured as a micro-electromechanical system (MEMS).

20. A method of forming an implantable neurological device, comprising:

providing a support tube;

providing a microelectrode film comprising a plurality of microelectrode elements, a longitudinal extension extending from a distal end of the microelectrode film, and a proximal end;

shaping the microelectrode film to form a cylindrical shape;

attaching the microelectrode film with an outer surface of the support tube such that the support tube defines a lumen through the cylindrical shape; and

inserting the longitudinal extension into the lumen.

21. The method of claim 20, comprising:

shaping the microelectrode film by heating the microelectrode film.