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Compositions and methods for targeted immunomodulatory antibodies and fusion proteins

  • US 9,441,044 B2
  • Filed: 03/11/2015
  • Issued: 09/13/2016
  • Est. Priority Date: 03/05/2010
  • Status: Active Grant
First Claim
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1. An isolated molecule comprising a targeting moiety fused with an immunomodulatory moiety, wherein:

  • (a) the targeting moiety specifically binds Epidermal Growth Factor Receptor (EGFR); and

    (b) the immunomodulatory moiety comprises an amino acid sequence of the extracellular domain of Transforming growth factor-beta receptor II (TGF-β

    RII).

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