Apparatus, methods and storage medium for performing polarization-based quadrature demodulation in optical coherence tomography

• US 9,441,948 B2
• Filed: 08/09/2006
• Issued: 09/13/2016
• Est. Priority Date: 08/09/2005
• Status: Active Grant

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Vakoc, Benjamin J., Yun, Seok-Hyun, Tearney, Guillermo J., Bouma, Brett Eugene
• Primary Examiner(s): LEE, HWA S
• Application Number:
  US11/502,330
• Publication Number:
  US 20070035743A1
• Time in Patent Office: 3,688 Days
• Field of Search: 356491-495, 356/497
• US Class Current: 1/1
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: G01B 2290/45 Multiple detectors for detecting interferometer signals
• CPC Class Codes: G01B 2290/70 Using polarization in the interferometer
• CPC Class Codes: G01B 9/02004 using frequency scans
• CPC Class Codes: G01B 9/02044 Imaging in the frequency domain, e.g. by using a spectrometer
• CPC Class Codes: G01B 9/02072 by calibration or testing of interferometer
• CPC Class Codes: G01B 9/02081 simultaneous quadrature detection, e.g. by spatial phase shifting
• CPC Class Codes: G01B 9/02091 Tomographic interferometers, e.g. based on optical coherence
• CPC Class Codes: G01J 2009/0265 with phase modulation
• CPC Class Codes: G01J 3/45 Interferometric spectrometry
• CPC Class Codes: G01N 21/21 Polarisation-affecting properties G01N21/19 takes precedence
• CPC Class Codes: G01N 21/274 Calibration, base line adjustment, drift correction
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B

Abstract

Apparatus, method and storage medium which can provide at least one first electro-magnetic radiation to a sample and at least one second electromagnetic radiation to a reference, such that the first and/or second electromagnetic radiations have a spectrum which changes over time. In addition, a first polarization component of at least one third radiation associated with the first radiation can be combined with a second polarization component of at least one fourth radiation associated with the second radiation with one another. The first and second polarizations may be specifically controlled to be at least approximately orthogonal to one another.

Claims

1. An apparatus comprising:

a first structural arrangement which includes a radiation generator source providing a particular radiation, a coupler and a beam splitter, the beam splitter splitting the particular radiation into a first optical electro-magnetic radiation which is to a sample and a second optical electro-magnetic radiation to a reference, wherein the source causes the particular radiation to have a spectrum which changes over time;

an optical second structural arrangement which includes a polarization beam combiner that combines a first polarization component of a third radiation based on the first radiation and a second polarization component of a fourth radiation based on the second radiation with one another, wherein the polarization beam combiner is part of a configuration which ensures that the first and second polarization components are at least approximately orthogonal to one another;

a third arrangement which includes a first optical detector that detects a first optical signal derived from a first interference between a first set of the first and second polarization components to generate a first digital signal, wherein the third arrangement includes a second optical detector that detects a second optical signal derived from a second interference between a second set of the first and second polarization components to generate a second digital signal; and

a fourth arrangement which includes a computer that modifies at least one of the first digital signal or the second digital signal based on particular data such that the first and second digital signals are in a quadrature relationship with one another.

2. The apparatus according to claim 1, further comprising a further structural arrangement which controls the computer to obtain the predetermined data based on at least one of a characteristic or a state of the fourth arrangement.

3. The apparatus according to claim 1, wherein the fourth arrangement generates a plurality of signals which include at least one of the particular signal or the further signal, determines statistical characteristics of the plurality of signals, and derives the particular data based on the statistical characteristics.

4. The apparatus according to claim 1, wherein the fourth arrangement specifically modifies a difference between a phase of the particular modified signal and a phase of the further modified signal to be closer to approximately nπ

+π

/2 than a difference between a phase of the particular signal or a phase of the further signal, where n is an integer and greater than 0.

5. The apparatus according to claim 1, wherein the computer specifically controls phases of the first interference and the second interference, respectively, to be substantially different from one another.

6. The apparatus according to claim 1, wherein the computer specifically controls a difference of phases of the first interference and the second interference, respectively, to be substantially nπ

+π

/2, where n is an integer and greater than or equal to 0.

7. The apparatus according to claim 1, wherein the fourth radiation and at least a portion of the third radiation have at least one delay with respect to one another, and further comprising a structural fifth arrangement which produces an image as a function of the at least one delay, the signal and the further signal.

8. The apparatus according to claim 7, wherein the at least one delay includes at least one positive delay section and at least one negative delay section, and wherein the fourth arrangement distinguishes between at least portions of the image derived from the third electro-magnetic radiation which has substantially positive and negative delay sections with respect to the fourth electro-magnetic radiation, and wherein at least one section of the image is based on a location of the reference.

9. The apparatus according to claim 8, wherein the fourth structural arrangement measures the sign and magnitude of the at least one delay.

10. The apparatus according to claim 1, wherein the second arrangement controls the first and second polarizations to be at least approximately orthogonal to one another.

11. The apparatus according to claim 1, further comprising a further structural arrangement including at least one of a polarization beam combiner or a birefringent optical element which specifically controls the first and second polarizations to be at least one of approximately or substantially orthogonal to one another.

12. The apparatus according to claim 1, wherein the second arrangement includes a polarization beam splitting arrangement.

13. The apparatus according to claim 1, further comprising a further arrangement including at least one of a polarization beam combiner or a birefringent optical element which specifically controls the first and second polarizations to be at least approximately orthogonal to one another.

14. The apparatus according to claim 1, wherein the third arrangement is a non-anatomical structure.

15. The apparatus according to claim 1, wherein the configuration of the second arrangement includes at least one of a polarization beam combiner or a birefringent optical element that ensures that the first and second polarization components are at least approximately orthogonal to one another for all polarization states of all of the third electro-magnetic radiations.

16. The apparatus according to claim 1, wherein the configuration of the second arrangement includes at least one of a polarization beam combiner or a birefringent optical element that ensures that the first and second polarization components of every combined respective one of the third and fourth electro-magnetic radiations are at least approximately orthogonal to one another.

17. The apparatus according to claim 1, wherein that the third radiation is based on a radiation coming from the sample, and the fourth radiation is based on a radiation coming from the reference.

18. A method, comprising:

providing a first optical electro-magnetic radiation to a sample and a second optical electro-magnetic radiation to a reference, wherein at least one of the electro-magnetic radiation or the second electro-magnetic radiation has a spectrum which changes over time;

combining a first polarization component of a third radiation based on the first radiation and a second polarization component of a fourth radiation based on the second radiation with one another;

providing a configuration to ensure that the first and second polarization components are at least approximately orthogonal to one another; and

detecting first optical signal derived from a first interference between a first set of the first and second polarization components to generate a first digital signal;

detecting a second optical signal derived from a second interference between a second set of the first and second polarization components to generate a second digital signal; and

modifying at least one of the first digital signal or the second digital signal based on particular data such that the first and second digital signals are in a quadrature relationship with one another.

19. The method according to claim 18, further comprising obtaining a plurality of signals which are at least one of the particular signal or the further signal, determining statistical characteristics of the plurality of signals, and deriving the determined data based on the statistical characteristics.

20. The method according to claim 18, further comprising specifically modifying a difference of a phase between the particular modified signal and the further modified signal to be closer to approximately nπ

+π

/2 than a difference between a phase of the particular signal and a phase of the further signal, where n is an integer and greater than or equal to 0.

21. The method according to claim 18, wherein phases of the first interference and the second interference, respectively, are substantially different from one another.

22. The method according to claim 18, wherein a difference of phases of the first interference and the second interference, respectively, are substantially nπ

+π

/2, where n is an integer and greater than or equal to 0.

23. The method according to claim 18, wherein the fourth radiation and at least a portion of the third radiation have at least one delay with respect to one another, and further comprising producing an image as a function of the delay, the signal and the further signal.

24. The method according to claim 23, wherein the at least one delay includes at least one positive delay section and at least one negative delay section, and further comprising distinguishing between at least portions of the image derived from the third electromagnetic radiation which has substantially positive and negative delay sections with respect to the fourth electromagnetic radiation, and wherein at least one section of the image is based on a location of the reference.

25. The method according to claim 24, further comprising measuring the sign and magnitude of the at least one delay.

26. A non-transitory storage medium which has software provided thereon, wherein the software, when executed, configures a computer to perform the steps comprising:

controlling a first optical electro-magnetic radiation to be provided to a sample and a second optical electro-magnetic radiation to be provided to a reference, wherein a radiation generator source causes at least one of the first electro-magnetic radiation or the second electro-magnetic radiation to have a spectrum which changes over time;

determining information associated with a combination of a first polarization component of a third radiation based on the first radiation and a second polarization component of a fourth radiation based on the second radiation with one another; and

ensuring that the first and second polarization components are at least approximately orthogonal to one another;

detecting first optical signal derived from a first interference between a first set of the first and second polarization components to generate a first digital signal;

detecting a second optical signal derived from a second interference between a second set of the first and second polarization components to generate a second digital signal; and

modifying at least one of the first digital signal or the second digital signal based on particular data such that the first and second digital signals are in a quadrature relationship with one another.