Methods for treatment of autism
First Claim
1. A method, comprising:
- (a) measuring the level of glutathione in its reduced or oxidized state, or total glutathione in a sample from a subject;
(b) measuring the level of gliotoxin in a sample from the subject;
(c) administering to the subject, having below normal glutathione and toxicologically significant gliotoxin levels in the sample from the subject, one or more of antioxidants, anti-fungal and or fungistatic compounds, N-acetyl-cysteine, glutathione, selenium-adenosyl methionine (SAM), N-chlorotaurine to increase a ratio of the level of glutathione to the level of gliotoxin in the subject.
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Abstract
The current invention is directed towards a rapid, reproducible test for the fungal virulence factors and associated affected compounds so that patients at risk for autism, cerebral palsy and other human diseases can be quickly identified, treated and possibly prevented. This includes a multitude of test protocols for both the mycotoxin gliotoxin and its relationship with glutathione—and relates the two molecules by a novel paradigm known as the Glutathione-Gliotoxin Index—(GGI) or Disease-Disorder Susceptibility Index—D/DSI, which indicates the Autism Susceptibility Index—(ASI). One testing device and protocol includes a cellular phone application with modification to test for susceptibility to autism and other disease states. Of particular relevance for autism is the role of glutathione depletion by gliotoxin, then by the anti-pyretic acetaminophen in the peri-vaccination period, which each result in oxidative stress and metal intoxication, by disrupting the metallothionein system, amongst other biochemical pathways and numerous enzyme systems.
42 Citations
20 Claims
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1. A method, comprising:
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(a) measuring the level of glutathione in its reduced or oxidized state, or total glutathione in a sample from a subject; (b) measuring the level of gliotoxin in a sample from the subject; (c) administering to the subject, having below normal glutathione and toxicologically significant gliotoxin levels in the sample from the subject, one or more of antioxidants, anti-fungal and or fungistatic compounds, N-acetyl-cysteine, glutathione, selenium-adenosyl methionine (SAM), N-chlorotaurine to increase a ratio of the level of glutathione to the level of gliotoxin in the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method, comprising:
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(a) measuring the level of glutathione in a sample from a subject; (b) measuring the level of gliotoxin in a sample from the subject; (c) if the level of glutathione in the sample from the subject is below normal and the level of gliotoxin in the sample is toxicologically significant, treating the subject to increase a ratio of the level of glutathione to the level of gliotoxin in the subject, wherein the treating comprises administering to the subject one or more of anti-oxidants, anti-fungal and or fungistatic compounds, N-acetyl-cysteine, glutathione, selenium-adenosyl methionine (SAM), N-chlorotaurine by either intranasal or rectal administration. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20)
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Specification