Blood glucose calibration system
First Claim
1. A blood glucose calibration system comprising:
- a noninvasive optical sensor configured to illuminate optical radiation and output sensor signals responsive to attenuation of the optical radiation from pulsatile blood flow in a tissue site;
a composite parameter generator responsive to the sensor signals so as to calculate a plurality of composite parameters corresponding to blood glucose;
a glucose estimator that calculates a plurality of uncalibrated blood glucose estimates according to the plurality of composite parameters;
a strip meter that reads test strips exposed to blood drawn from the person so as to generate a plurality of glucose calibrations; and
a glucose calibrator that generates a plurality of calibrated blood glucose estimates from the plurality of uncalibrated blood glucose estimates according to the glucose calibrations,wherein the plurality of composite parameters comprise at least one of Gu/X and Gu*X, where “
Gu”
represents blood glucose and “
X”
represents a non-glucose blood parameter.
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Accused Products
Abstract
A blood glucose calibration system has a noninvasive sensor that attaches to a person'"'"'s tissue site so as to generate multi-stream physiological data responsive to that person'"'"'s blood constituents. Composite parameters, each in the form of a mathematical combination of invasive blood panel parameters, are derived from a general population and are responsive to the multi-stream physiological data. A population-based, blood glucose estimate for that person is derived from a weighted and scaled combination of these composite parameters. An individualized blood glucose estimate is then derived from the population-based blood glucose estimate and intermittent invasive test strip measurements of that particular individual.
973 Citations
16 Claims
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1. A blood glucose calibration system comprising:
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a noninvasive optical sensor configured to illuminate optical radiation and output sensor signals responsive to attenuation of the optical radiation from pulsatile blood flow in a tissue site; a composite parameter generator responsive to the sensor signals so as to calculate a plurality of composite parameters corresponding to blood glucose; a glucose estimator that calculates a plurality of uncalibrated blood glucose estimates according to the plurality of composite parameters; a strip meter that reads test strips exposed to blood drawn from the person so as to generate a plurality of glucose calibrations; and a glucose calibrator that generates a plurality of calibrated blood glucose estimates from the plurality of uncalibrated blood glucose estimates according to the glucose calibrations, wherein the plurality of composite parameters comprise at least one of Gu/X and Gu*X, where “
Gu”
represents blood glucose and “
X”
represents a non-glucose blood parameter. - View Dependent Claims (2, 3, 4, 5)
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6. A glucose calibration method comprising:
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deriving one or more pre-selected composite parameters, each responsive to a noninvasive multi-stream sensor in communications with a person'"'"'s blood flow; estimating a plurality of blood glucose values over time from a combination of the one or more pre-selected composite parameters; generating a plurality of invasive blood glucose calibrations over time from a corresponding plurality of test strip readings; and calculating a plurality of individualized blood glucose values from a combination of the noninvasive blood glucose values and the invasive blood glucose calibrations, the invasive blood glucose calibrations intermittently updating the individualized blood glucose values, wherein the one or more preselected composite parameters comprise at least one of Gu/X and Gu*X, where “
Gu”
represents blood glucose and “
X”
represents a non-glucose blood parameter. - View Dependent Claims (7, 8, 9, 10, 11, 12)
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13. A glucose calibration apparatus comprising:
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an optical sensor means for generating physiological data responsive to the person'"'"'s blood constituents; a composite parameter generator means for generating composite parameters in the form of mathematical combinations of blood constituents based on the physiological data; a glucose estimator means for deriving noninvasive glucose estimate from a weighted and scaled combination of a composite parameters subset of the composite parameters; and a glucose calibrator means for calibrating the noninvasive glucose estimate based on an invasive test strip measurement of the person, wherein the composite parameters comprise at least one of Gu/X and Gu*X, where “
Gu”
represents blood glucose and “
X”
represents a non-glucose blood parameter. - View Dependent Claims (14, 15, 16)
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Specification