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Bone treatment systems and methods

  • US 9,445,854 B2
  • Filed: 02/27/2009
  • Issued: 09/20/2016
  • Est. Priority Date: 02/01/2008
  • Status: Active Grant
First Claim
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1. A bone cement system, comprising:

  • a pre-mixture comprising;

    a first monomer-carrying component; and

    a second polymer-carrying component, separate from the first monomer-carrying component, the second polymer-carrying component comprising a plurality of bead populations that have different mean particle sizes and an initiator in different amounts, the second polymer-carrying component comprising;

    a first polymer bead population having a first mean particle size and including the initiator at a first weight percent of the first polymer bead population, wherein the initiator is integrated throughout the volume of each of the first polymer beads;

    a second polymer bead population having a second mean particle size smaller than the first mean particle size and including the initiator at a second weight percent of the second polymer bead population that is higher than the first weight percent, wherein the initiator is integrated throughout the volume of each of the second polymer; and

    a third polymer bead population having a third mean particle size smaller than the second mean particle size and including an initiator at a third weight percent of the third polymer bead population that is lower than the first weight percent,wherein upon forming a mixture of the first monomer-carrying component and the second polymer-carrying component, different dissolution rates and the different initiator amounts of the plurality of bead populations control an availability of the initiator in the mixture that is sufficiently low and slow-varying over time, such that the temperature of the mixture remains below 75°

    C. and, after an initial exposure period post-mixing, a time-viscosity curve slope remains less than or equal to about 200 Pa·

    s/minute until the mixture reaches a viscosity of about 2500 Pa·

    s.

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