Method of treating snoring and obstructive sleep apnea
First Claim
1. A method of treating snoring and/or obstructive sleep apnea in a subject in need of such treatment, comprising:
- providing to the subject a buccal bioadhesive strip adapted to bind a mucosal membrane by applying said strip to the tissue of the soft palate to stiffen the tissue to reduce vibration, said strip comprising at least one coating layer having a surface topography for resisting bioadhesion, said at least one layer comprising a polymer, said coating layer having a pattern defined by a plurality of spaced apart features attached to or projected into a base surface, said plurality of features each having at least one microscale dimension and having at least one neighboring feature having a substantially different geometry, wherein an average spacing between adjacent ones of said features is between 0.5 and 5 μ
m in at least a portion of said coating layer, said coating layer resisting bioadhesion as compared to said base surface.
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Accused Products
Abstract
A method, system and device for addressing the reduction of snoring includes a removable or dissolvable strip of material that adhere to mucosal tissue of a person'"'"'s soft palate to provide stiffening support therefore, thus reducing the occurrence of vibration of such tissue during sleep. Preferred embodiments include of a specially textured surface, either one both or at least the outer side of an adhesive strip (the side facing away from the mucosal tissue to which it is attached) that has anti-microbial characteristics, bioluminescent expressions, etc. and a surface topography that resists bioadhesion of undesired bacteria that are typically present in a human'"'"'s mouth.
213 Citations
20 Claims
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1. A method of treating snoring and/or obstructive sleep apnea in a subject in need of such treatment, comprising:
providing to the subject a buccal bioadhesive strip adapted to bind a mucosal membrane by applying said strip to the tissue of the soft palate to stiffen the tissue to reduce vibration, said strip comprising at least one coating layer having a surface topography for resisting bioadhesion, said at least one layer comprising a polymer, said coating layer having a pattern defined by a plurality of spaced apart features attached to or projected into a base surface, said plurality of features each having at least one microscale dimension and having at least one neighboring feature having a substantially different geometry, wherein an average spacing between adjacent ones of said features is between 0.5 and 5 μ
m in at least a portion of said coating layer, said coating layer resisting bioadhesion as compared to said base surface.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method of treating snoring and/or obstructive sleep apnea in a subject in need of such treatment, comprising:
providing to a subject a buccal bioadhesive strip adapted to bind a mucosal membrane by applying said strip to the subject'"'"'s tissue of the soft palate to stiffen the tissue and to reduce vibration of the tissue, the strip having a first and second side, the first side having a bioadhesive that is adapted to bind to a mucosal membrane for at least 1 hour while inside a person'"'"'s mouth, wherein said strip has at least one layer comprising a polymer and extends over a majority of the soft palate, said second side resisting bioadhesion as compared to said first side and having a textured surface that has an anti-microbial characteristic comprising a textured surface having a topography that resists bioadhesion of bacteria present in a human'"'"'s mouth, and wherein said bioadhesive is selected from the group consisting of a carboxylated polymer, poly(acrylic acid), crosslinked polyvinyl pyrrolidone, crosslinked poly(acrylic acid), polycarbophil, carbomer, and a water soluble salt of a co-polymer of methyl vinyl ether and maleic acid. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A method of treating snoring and/or obstructive sleep apnea in a subject in need of such treatment, comprising:
providing to a subject a buccal bioadhesive strip adapted to bind a mucosal membrane by applying said strip to the subject'"'"'s tissue of the soft palate to stiffen the tissue and to reduce vibration of the tissue, the strip having a first and second side, the first side having a bioadhesive that is adapted to bind to a mucosal membrane for at least 1 hour while inside a person'"'"'s mouth, wherein said strip has at least one layer comprising a polymer and extends over a majority of the soft palate, said second side resisting bioadhesion as compared to said first side and having at least one textured surface that has an anti-microbial characteristic that comprises a textured surface having a topography that resists bioadhesion of bacteria present in a human'"'"'s mouth;
wherein the strip is non-biodegradable and is porous, and wherein said bioadhesive is selected from the group consisting of a carboxylated polymer, poly(acrylic acid), crosslinked polyvinyl pyrrolidone, and crosslinked poly(acrylic acid); and
wherein said strip does not result in permanent tissue changes that affect the physical characteristics of the soft palate.
Specification