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Scaffolds for cell transplantation

  • US 9,446,107 B2
  • Filed: 06/25/2015
  • Issued: 09/20/2016
  • Est. Priority Date: 12/13/2005
  • Status: Active Grant
First Claim
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1. A cancer vaccine device comprising a scaffold composition comprising a polymer matrix and having open, interconnected macropores;

  • a granulocyte-macrophage colony stimulating factor (GM-CSF) that recruits immune cells selected from macrophages, T-cells, B-cells, NK cells, and dendritic cells;

    a tumor antigen; and

    an immune response-promoting bioactive factor comprising an oligonucleotide, wherein the GM-CSF, the tumor antigen, or the immune response-promoting bioactive factor is incorporated into or coated onto said scaffold composition.

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