Highly active nucleoside derivative for the treatment of HCV
First Claim
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1. A compound of Formula I or a pharmaceutically acceptable salt thereof, wherein Formula I is
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Abstract
A deuterated nucleoside analog of the formula
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- and the pharmaceutically acceptable salts thereof are provided by this disclosure. The disclosure also includes pharmaceutical compositions comprising a compound or salt of the formula and a carrier. Compounds and salts of this formula are useful for treating viral infections, including HCV infections. A method for treating a host afflicted with hepatitis C or other disorders is also presented that includes administering an effective treatment amount of a nucleoside or nucleotide that has deuterium with at least 50% enrichment at the 5′-position of the nucleoside or nucleotide.
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13 Claims
- 1. A compound of Formula I or a pharmaceutically acceptable salt thereof, wherein Formula I is
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