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Production of saturated fatty alcohols from engineered microorganisms

  • US 9,447,436 B2
  • Filed: 12/13/2012
  • Issued: 09/20/2016
  • Est. Priority Date: 12/20/2011
  • Status: Active Grant
First Claim
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1. An engineered bacterial microorganism comprising at least one polynucleotide encoding at least one heterologous fatty acyl-ACP reductase enzyme (FAR), wherein said FAR comprises an amino acid sequence having at least 80% sequence identity to SEQ ID NO:

  • 28 and has fatty alcohol forming acyl-CoA reductase activity, and a first recombinant polynucleotide encoding a FabZ enzyme, wherein said FabZ enzyme comprises the amino acid sequence set forth in SEQ ID NO;

    8, wherein the engineered bacterial microorganism produces a fatty alcohol composition comprising C10 to C18 fatty alcohols.

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