Device and method for non-invasive collection of colorectal mucocellular layer and disease detection
First Claim
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1. A non-invasive method for collecting a sample of intestinal or bowel cells or cell fragments comprising:
- taking a swab of mucocellular layer material that originates from said bowel or intestine and is excreted during defaecation, from the exterior surface of the anal area in the vicinity of the exterior opening of the anal canal, wherein said swab is taken following defaecation; and
(a) collecting the sample of intestinal or bowel cells or cell fragments from the swab of mucocellular layer material, wherein collecting includes transferring the sample of intestinal or bowel cells or cell fragments from the swab of mucocellular layer material into a medium for sample storage or lysis; and
analysing said mucocellular layer material from said sample for the presence of one or more bowel disease-specific markers or analyzing cell morphology of the mucocellular layer material;
or(b) collecting a sample of intestinal or bowel cells or cell fragments from the swab of mucocellular layer material and analyzing cell morphology of the mucocellular layer material.
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Abstract
The present invention relates to a device and a method for collecting a sample of colorectal mucocellular layer excreted immediately following the natural act of defaecation from the surface of the anal area of a human subject, and preservation and analysis of the collected sample for detecting diagnostically informative disease biomarkers.
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26 Claims
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1. A non-invasive method for collecting a sample of intestinal or bowel cells or cell fragments comprising:
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taking a swab of mucocellular layer material that originates from said bowel or intestine and is excreted during defaecation, from the exterior surface of the anal area in the vicinity of the exterior opening of the anal canal, wherein said swab is taken following defaecation; and (a) collecting the sample of intestinal or bowel cells or cell fragments from the swab of mucocellular layer material, wherein collecting includes transferring the sample of intestinal or bowel cells or cell fragments from the swab of mucocellular layer material into a medium for sample storage or lysis; and
analysing said mucocellular layer material from said sample for the presence of one or more bowel disease-specific markers or analyzing cell morphology of the mucocellular layer material;
or(b) collecting a sample of intestinal or bowel cells or cell fragments from the swab of mucocellular layer material and analyzing cell morphology of the mucocellular layer material. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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Specification