Optical biosensor and biosensing system with resonant feedback controls

• US 9,448,181 B2
• Filed: 02/28/2014
• Issued: 09/20/2016
• Est. Priority Date: 03/14/2013
• Status: Active Grant

• Current Assignee: Samsung Electronics Co. Ltd.
• Original Assignee: Samsung Electronics Co. Ltd.
• Inventors: Lee, Kwang-hyun, Hong, Seok-yong
• Primary Examiner(s): Legasse, Jr., Francis M
• Application Number:
  US14/192,926
• Publication Number:
  US 20140263948A1
• Time in Patent Office: 935 Days
• US Class Current: 1/1
• CPC Class Codes: G01N 1/00 Sampling; Preparing specimens for investigation
• CPC Class Codes: G01N 21/7746 the waveguide coupled to a cavity resonator

Abstract

An optical biosensor is provided. The optical biosensor includes a biosensing unit, a detection unit, and a feedback circuit. The biosensing unit is configured to receive an input optical signal, sense a biomaterial, and generate a sensed optical signal. The detecting unit is configured to convert the sensed optical signal into an electrical signal and output the electrical signal as a detection signal. The feedback circuit is configured to output a feedback signal. The feedback signal is generated based on the detection signal and is changed according to a changed amount of a resonant wavelength of the biosensing unit.

Claims

1. An optical biosensor, comprising:

a biosensing unit configured to receive an input optical signal, sense a target biomaterial, and generate a sensed optical signal;

a detecting unit configured to convert the sensed optical signal into an electrical signal and output the electrical signal as a detection signal; and

a feedback circuit configured to output a feedback signal generated based on the detection signal, wherein the feedback signal is changed based on change in a resonant wavelength of the biosensing unit.

2. The optical biosensor of claim 1, wherein the feedback circuit controls the resonant wavelength of the biosensing unit to be equal to a wavelength of the input optical signal by using the feedback signal.

3. The optical biosensor of claim 1, wherein the feedback circuit controls a wavelength of the input optical signal to be equal to the resonant wavelength of the biosensing unit by using the feedback signal.

4. The optical biosensor of claim 1, wherein the feedback signal is a voltage signal or a current signal.

5. The optical biosensor of claim 1, further comprising an optical source providing the input optical signal.

6. The optical biosensor of claim 1, wherein the biosensing unit, the detecting unit, and the feedback circuit are formed on a same substrate.

7. The optical biosensor of claim 1, further comprising a signal processing unit calculating a concentration of the target biomaterial by calculating a difference between a reference feedback signal generated when a probe biomaterial is attached to the biosensing unit and a sensing feedback signal generated when the target biomaterial is combined into the probe biomaterial.

8. The optical biosensor of claim 2, wherein the biosensing unit comprises:

a resonator configured to provide the resonant wavelength and to output the sensed optical signal; and

a phase shifter configured to receive the feedback signal and change the resonant wavelength of the resonator in response to the feedback signal.

9. The optical biosensor of claim 2, where the biosensing unit comprises:

an optical waveguide configured to receive the input optical signal;

a ring resonator configured to provide the resonant wavelength and to output the sensed optical signal through a gap interposed between the optical waveguide and the ring resonator; and

a phase shifter configured to change the resonant wavelength of the ring resonator in response to the feedback signal.

10. The optical biosensor of claim 2, wherein the biosensing unit comprises:

a first optical waveguide configured to receive the input optical signal;

a ring resonator configured to provide the resonant wavelength and to output the sensed optical signal through a gap interposed between the first optical waveguide and the ring resonator;

a phase shifter configured to change the resonant wavelength of the ring resonator in response to the feedback signal; and

a second optical waveguide configured to output the sensed optical signal through a gap interposed between the ring resonator and the second optical waveguide.

11. The optical biosensor of claim 2, wherein the biosensing unit comprises:

a first optical waveguide configured to receive the input optical signal;

a cavity resonator configured to provide the resonant wavelength and to output the sensed optical signal;

a second optical waveguide configured to receive the sensed optical signal; and

a phase shifter configured to change the resonant wavelength of the cavity resonator.

12. The optical biosensor of claim 11, wherein the cavity resonator includes a Bragg reflector.

13. The optical biosensor of claim 5, wherein the optical source is configured to change the wavelength of the input optical signal in response to the feedback signal.

14. A biosensing system, comprising:

a biosensor chip configured to sense a target biomaterial based on an input optical signal, and output a feedback signal; and

a signal processing unit configured to analyze the feedback signal and calculate a concentration of the target biomaterial,

wherein the biosensor chip comprises;

a biosensing unit configured to receive the input optical signal, sense the target biomaterial, and generate a sensed optical signal;

a detecting unit configured to convert the sensed optical signal into an electrical signal and output the electrical signal as a detection signal; and

a feedback circuit configured to output the feedback signal generated based on the detection signal,

wherein the feedback circuit controls a resonant wavelength of the biosensing unit to be equal to a wavelength of the input optical signal by using the feedback signal.

15. The biosensing system of claim 14, wherein the biosensing unit comprises a resonator configured to provide the resonant wavelength and to output the sensed optical signal, wherein the signal processing unit calculates the concentration of the target biomaterial by calculating a difference between a reference feedback signal generated when a probe biomaterial is attached to the biosensing unit and a sensing feedback signal generated when the target biomaterial is combined into the probe biomaterial.

16. The biosensing system of claim 14, wherein the biosensing system further comprises an optical source configured to generate the input optical signal, wherein the optical source is integrated on the substrate which the biosensor chip is formed.

17. A biosensing system comprising:

a biosensor chip configured to sense a target biomaterial based on an input optical signal, and output a feedback signal; and

a signal processing unit configured to analyze the feedback signal and calculate a concentration of the target biomaterial,

wherein the biosensor chip comprises;

a biosensing unit configured to receive the input optical signal, sense the target biomaterial, and generate a sensed optical signal;

a detecting unit configured to convert the sensed optical signal into an electrical signal and output the electrical signal as a detection signal; and

a feedback circuit configured to output the feedback signal generated based on the detection signal,

wherein the feedback circuit controls a wavelength of the input optical signal to be equal to a resonant wavelength of the biosensing unit by using the feedback signal.