Depth-selective fiber-optic probe

• US 9,451,885 B2
• Filed: 12/15/2011
• Issued: 09/27/2016
• Est. Priority Date: 12/22/2010
• Status: Active Grant

• Current Assignee: University of Pittsburgh of The Commonwealth System of Higher Education
• Original Assignee: University of Pittsburgh of The Commonwealth System of Higher Education
• Inventors: Liu, Yang
• Primary Examiner(s): Roy, Baisakhi
• Application Number:
  US13/991,459
• Publication Number:
  US 20140249427A1
• Time in Patent Office: 1,748 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 1/00096 Optical elements
• CPC Class Codes: A61B 1/00167 Details of optical fibre bundles, e.g. shape or fibre distribution
• CPC Class Codes: A61B 1/0017 Details of single optical fibres, e.g. material or cladding
• CPC Class Codes: A61B 1/00188 with focusing or zooming features
• CPC Class Codes: A61B 1/07 using light-conductive means, e.g. optical fibres
• CPC Class Codes: A61B 2560/0233 Optical standards
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/443 Evaluating skin constituents, e.g. elastin, melanin, water
• CPC Class Codes: A61B 5/444 Evaluating skin marks, e.g. mole, nevi, tumour, scar
• CPC Class Codes: G01N 2021/4742 comprising optical fibres
• CPC Class Codes: G01N 21/474 Details of optical heads therefor, e.g. using optical fibres
• CPC Class Codes: G01N 2201/0639 Sphere lens
• CPC Class Codes: G02B 6/32 having lens focusing means positioned between opposed fibre ends with lens being an integral part of the single fibre end G02B6/262
• CPC Class Codes: Y10T 29/49826 Assembling or joining

Abstract

Systems and methods that facilitate analysis of superficial tissue based at least in part on a depth-selective fiber optic probe are discussed herein. The depth-selective fiber optic probe can include an illumination fiber for providing light to the superficial tissue, a collection fiber for collected reflected light, a ball lens that couples the fibers, and a protective overtube that houses the ball lens and fibers. The distances between the ball lens and fibers and between the fibers can be optimized based on several factors, such as by minimizing the illumination spot size, maximizing the overlap between the illumination and collection spots, and based on the angle between the illumination and collection beams.

Claims

1. A fiber-optic probe that facilitates characterization of superficial tissue, comprising:

an illumination fiber, wherein the illumination fiber is a multi-mode optic fiber;

a collection fiber, wherein the collection fiber is a multi-mode optic fiber;

a ball lens that couples the illumination fiber and collection fiber; and

a protective overtube that houses the illumination fiber, the collection fiber, and the ball lens, wherein the arrangement of the illumination fiber, the collection fiber, and the ball lens facilitates a constant penetration depth and are arranged based on an optimization of a first diameter of an illumination spot, a second diameter of a collection spot, a separation distance between the illumination spot and the collection spot, and an angle between an illumination beam and a collection beam, wherein the optimization maximizes an overlap between an illumination area of the illumination fiber and a collection area of the collection fiber.

2. The probe of claim 1, further comprising a spectrometer that facilitates analysis of one or more signals collected via the collection fiber.

3. The probe of claim 1, further comprising an illumination source coupled to the illumination fiber, wherein the illumination source facilitates illumination of the superficial tissue via the illumination fiber and the ball lens.

4. The probe of claim 1, wherein the optimization is based at least in part on a Monte Carlo or ray tracing simulation of photon trajectories associated with the probe.

5. The probe of claim 1, wherein the illumination fiber and the collection fiber each have a core fiber diameter of between 50 μ

m and 200 μ

m.

6. The probe of claim 1, wherein the ball lens has an index of refraction of 1.85.

7. The probe of claim 1, wherein the ball lens has a diameter of 2 mm.

8. The probe of claim 1, wherein the distance between the illumination and collection fibers is 0.625 mm and the distance between the ball lens and the illumination and collection fibers is 0.563 mm.

9. The probe of claim 1, wherein the penetration depth is independent of a scattering coefficient and an anisotropy factor.

10. The probe of claim 1, wherein the probe has a penetration depth less than or equal to 200 μ

m.

11. A method of fabricating a depth-selective probe, comprising:

selecting at least two multi-mode fibers based at least in part on one or more properties of the at least two multi-mode fibers, wherein the at least two multi-mode fibers comprise an illumination fiber and a collection fiber;

selecting a high-index ball lens; and

arranging the high-index ball lens and the at least two multi-mode fibers within a protective overtube, wherein the high-index ball lens couples the at least two multi-mode fibers, the arranging comprising;

optimizing a distance between the ball lens and the at least two multi-mode fibers;

optimizing the distance between the at least two multi-mode fibers; and

optimizing a signal to noise ratio of the depth-selective probe;

wherein the optimizations include;

minimizing a spot size of the illumination fiber;

minimizing specular reflection;

maximizing an overlap between an illumination area of the illumination fiber and a collection area of the collection fiber; and

maximizing a collection angle with respect to an illumination beam.

12. The method of claim 11, wherein the arranging comprises employing a Monte Carlo simulation or ray tracing simulation of photon trajectories associated with the probe.

13. The method of claim 11, wherein the ball lens has an index of refraction of 1.85.

14. The method of claim 11, wherein the illumination fiber and the collection fiber each have a core fiber diameter of between 50 μ

m and 200 μ

m.