Differential neurostimulation therapy driven by physiological therapy

• US 9,451,891 B2
• Filed: 12/05/2014
• Issued: 09/27/2016
• Est. Priority Date: 04/05/2000
• Status: Expired due to Term

• Current Assignee: Neuropace Inc.
• Original Assignee: Neuropace Inc.
• Inventors: Pless, Benjamin D., Tcheng, Thomas K.
• Primary Examiner(s): GETZOW, SCOTT M
• Application Number:
  US14/562,135
• Publication Number:
  US 20150087934A1
• Time in Patent Office: 662 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/0006 ECG or EEG signals
• CPC Class Codes: A61B 5/0022 Monitoring a patient using a global network, e.g. telephone networks, internet
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence
• CPC Class Codes: A61B 5/076 Permanent implantations telemetry using implanted circuitry A61B5/0031; implanted stimulators for therapy A61N1/3605, A61N1/362, A61N1/372
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/316 Modalities, i.e. specific diagnostic methods
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/389 Electromyography [EMG]
• CPC Class Codes: A61B 5/4812 Detecting sleep stages or cycles
• CPC Class Codes: A61B 5/4836 Diagnosis combined with treatment in closed-loop systems or methods A61B5/0036 takes precedence
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: A61B 5/743 Displaying an image simultaneously with additional graphical information, e.g. symbols, charts, function plots
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0539 Anchoring of brain electrode systems, e.g. within burr hole
• CPC Class Codes: A61N 1/36064 Epilepsy
• CPC Class Codes: A61N 1/36067 : Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/36078 : Inducing or controlling sleep or relaxation non-implantable stimulator A61M21/00
• CPC Class Codes: A61N 1/36135 : using physiological parameters
• CPC Class Codes: A61N 1/36139 : with automatic adjustment

Abstract

An implantable neurostimulator system adapted to provide therapy for various neurological disorders is capable of varying therapy delivery strategies based on the context, physiological or otherwise, into which the therapy is to be delivered. Responsive and scheduled therapies can be varied depending on various sensor measurements, calculations, inferences, and device states (including elapsed times and times of day) to deliver an appropriate course of therapy under the circumstances.

Claims

1. An external component of an implantable medical device system, said external component comprising:

a software operating program and associated hardware configured to process EEG signals received from a device remote from the external component, the EEG signals corresponding to a detection of a neurological event by an implantable medical device, and being stored in a memory of the remote device; and

a communication component configured to establish a communication link with the remote device to enable receipt of the EEG signals from the remote device;

wherein the software operating program and associated hardware is configured to process the EEG signals received from the remote device to simulate the detection of the neurological event.

2. The external component of claim 1, wherein the remote device comprises the implantable medical device and the communication link comprises a wireless link between the implantable medical device and the external component.

3. The external component of claim 1, wherein the remote device comprises a database and the communication link comprises a wireless link between the database and the external component.

4. The external component of claim 1, wherein the software operating program and associated hardware of the external component is further configured to at least one of process, store, playback and display on the display of the external component at least one of a representation of the EEG signals, one or more EEG parameters derived by the implantable medical device, a neurological event detected in the EEG signals based on the one or more derived EEG parameters, and a form of neuromodulation delivered by the implantable medical device responsive to a detected neurological event.

5. The external component of claim 4, wherein a display of EEG parameters on the external component is directly associated with a display of a representation of the EEG signals.

6. The external component of claim 4, wherein a display of EEG parameters on the display of the external component is indirectly associated with a display of a representation of the EEG signals.

7. The external component of claim 1, wherein the software operating program and associated hardware of the external component is further configured to at least one of process, store, playback and display operational parameters of the implantable medical device on the display of the external component.

8. A method of simulating a detection of a neurological event by an implantable medical device at an external component, said method comprising:

establishing a communication link between the external component and a remote device to enable receipt of EEG signals from the remote device, the EEG signals corresponding to a detection of a neurological event by the implantable medical device, and being stored in a memory of the remote device; and

processing the EEG signals received from the remote device to simulate the detection of the neurological event.

9. The method of claim 8, wherein the remote device comprises the implantable medical device and the communication link comprises a wireless link between the implantable medical device and the external component.

10. The method of claim 8, wherein the remote device comprises a database and the communication link comprises a wireless link between the database and the external component.

11. The method of claim 8, wherein processing comprises at least one of processing, storing, playing back and displaying on the display of the external component at least one of a representation of the EEG signals, one or more EEG parameters derived by the implantable medical device, a neurological event detected in the EEG signals based on the one or more derived EEG parameters, and a form of neuromodulation delivered by the implantable medical device responsive to a detected neurological event.

12. The method of claim 11, wherein displaying comprises directly associating a display of EEG parameters on the external component with a display of a representation of the EEG signals.

13. The method of claim 11, wherein displaying comprises indirectly associating a display of EEG parameters on the display of the external component with a display of a representation of the EEG signals.

14. The method of claim 8, wherein processing further comprises at least one of processing, storing, playing back and displaying operational parameters of the implantable medical device on the display of the external component.