Embolization device constructed from expansile polymer

• US 9,451,963 B2
• Filed: 07/19/2012
• Issued: 09/27/2016
• Est. Priority Date: 06/15/2006
• Status: Active Grant

• Current Assignee: Microvention Incorporated (Terumo Corporation)
• Original Assignee: Microvention Incorporated (Terumo Corporation)
• Inventors: Cruise, Gregory M., Constant, Michael, Tran, Terrance, Gulachenski, Joseph
• Primary Examiner(s): Tran, Susan
• Assistant Examiner(s): CRAIGO, WILLIAM A
• Application Number:
  US13/553,275
• Publication Number:
  US 20120283769A1
• Time in Patent Office: 1,531 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 17/12113 within an aneurysm
• CPC Class Codes: A61B 17/1214 Coils or wires
• CPC Class Codes: A61B 17/12145 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/12154 having stretch limiting means
• CPC Class Codes: A61B 17/12168 having a mesh structure A61B17/1214 takes precedence
• CPC Class Codes: A61B 17/1219 expandable in contact with liquids
• CPC Class Codes: A61L 2400/04 Materials for stopping bleeding
• CPC Class Codes: A61L 31/00 Materials for other surgical articles , e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices shape or structure of stent-grafts A61F2/07, of stents A61F2/82, of surgical gloves A61B42/00, of surgical drapes A61B46/00, of occluding devices A61B17/12022
• CPC Class Codes: A61L 31/022 Metals or alloys
• CPC Class Codes: A61L 31/041 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 31/048 obtained by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 31/145 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 31/146 Porous materials, e.g. foams or sponges
• CPC Class Codes: C08L 71/02 Polyalkylene oxides

Abstract

Devices for the occlusion of body cavities, such as the embolization of vascular aneurysms and the like, and methods for making and using such devices. The devices may be comprised of novel expansile materials, novel infrastructure design, or both. The devices provided are very flexible and enable deployment with reduced or no damage to bodily tissues, conduits, cavities, etceteras.

Claims

1. An implant delivery device comprising:

an occlusion device consisting essentially of;

an elongated expansile element composed substantially of expansile material comprising a poly(ethylene glycol) macromer; and

a microcoil comprising a plurality of loops forming a helical shape, wherein the loops are spaced by gaps, wherein at least one gap has a distance of about 0.00025 inches to about 0.2 inches helically disposed around said expansile element, wherein the at least one gap is dimensioned to allow the elongated expansile element to expand through the at least one gap and wherein the occlusion device has a bending resistance of about 0.1 mg to 25 mg.

2. The occlusion device of claim 1, wherein said microcoil is between about 0.005 inches and about 0.035 inches in diameter.

3. The occlusion device of claim 1, wherein said microcoil is about 0.012 inches in diameter.

4. The occlusion device of claim 3, wherein said microcoil has a filar of about 0.002 inches.

5. The occlusion device of claim 4, wherein the at least one gap has a distance of about 0.0013 inches.

6. The occlusion device of claim 1, wherein said microcoil has a filar between about 0.0005 inches and about 0.01 inches.

7. The occlusion device of claim 1, wherein said microcoil has a filar between about 0.00075 inches and about 0.004 inches.

8. The occlusion device of claim 1, wherein said elongated expansile element is secured to said microcoil in a stretched configuration.

9. The occlusion device of claim 1, wherein the at least one gap has a distance of about 0.00025 inches to about 0.005 inches.

10. The occlusion device of claim 1, wherein the at least one gap has a distance of about 0.0013 inches.

11. The occlusion device of claim 1, wherein said elongated expansile element is secured to said microcoil in a stretched configuration that is between about 125% and about 600% of its initial length.

12. The occlusion device of claim 1, wherein said microcoil has a diameter of between about 0.008 inches and about 0.016 inches.

13. The occlusion device of claim 1, wherein said microcoil has a filar of between about 0.0005 inches and about 0.01 inches.

14. The occlusion device of claim 13, wherein said microcoil has a filar of between about 0.00075 inches and about 0.004 inches.

15. An implant delivery device comprising:

an occlusion device consisting essentially of;

an elongated expansile element composed substantially of expansile material comprising a poly(ethylene glycol) macromer; and

a carrier element comprising a plurality of loops forming a helical shape, wherein the loops are spaced by gaps, wherein at least one gap has a distance of about 0.00025 inches to about 0.2 inches helically disposed around said expansile element, wherein the at least one gap is dimensioned to allow the elongated expansile element to expand through the at least one gap and wherein the occlusion device has a bending resistance of about 0.1 mg to about 25 mg.

16. The occlusion device of claim 15, wherein said carrier element has a diameter of about 0.012 inches and a filar of about 0.002 inches.

17. The occlusion device of claim 16, wherein the at least one gap has a distance of about 0.0013 inches.

18. The occlusion device of claim 15, wherein said carrier element has a diameter of between about 0.008 inches and about 0.016 inches.

19. The occlusion device of claim 15, wherein said carrier element has a filar of between about 0.0005 inches and about 0.01 inches.

20. The occlusion device of claim 19, wherein said carrier element has a filar of between about 0.00075 inches and about 0.004 inches.

21. The occlusion device of claim 15, wherein said carrier element is between about 0.005 inches and about 0.035 inches in diameter.

22. The occlusion device of claim 21, wherein said carrier element has a filar between about 0.0005 inches and about 0.01 inches.

23. The occlusion device of claim 22, wherein the at least one gap has a distance of about 0.00025 inches to about 0.005 inches.

24. The occlusion device of claim 23, wherein said elongated expansile element is secured to said carrier element in a stretched configuration that is between about 125% and about 600% of its initial length.

25. The occlusion device of claim 22, wherein the at least one gap has a distance of about 0.0013 inches.

26. An implant delivery device comprising:

an occlusion device consisting essentially of;

a filament formed substantially of expansile material comprising a poly(ethylene glycol) macromer; and

a carrier element comprising a plurality of loops forming a helical shape, wherein the loops are spaced by gaps, wherein at least one gap has a distance of about 0.00025 inches to about 0.2 inches helically disposed around said filament, wherein the at least one gap is dimensioned to allow the elongated expansile element to expand through the at least one gap and wherein the occlusion device has a bending resistance of about 0.1 mg to about 25 mg.

27. The occlusion device of claim 26, wherein said carrier element has a diameter of about 0.012 inches and a filar of about 0.002 inches.

28. The occlusion device of claim 27, wherein the at least one gap has a distance of about 0.0013 inches.

29. The occlusion device of claim 26, wherein said carrier element has a diameter of between about 0.008 inches and about 0.016 inches.

30. The occlusion device of claim 26, wherein said carrier element has a filar of between about 0.0005 inches and about 0.01 inches.

31. The occlusion device of claim 30, wherein said carrier element has a filar of between about 0.00075 inches and about 0.004 inches.

32. The occlusion device of claim 26, wherein said carrier element is between about 0.005 inches and about 0.035 inches in diameter.

33. The occlusion device of claim 26, wherein said carrier element has a filar between about 0.0005 inches and about 0.01 inches.

34. The occlusion device of claim 26, wherein the at least one gap has a distance of about 0.00025 inches to about 0.005 inches.

35. The occlusion device of claim 26, wherein said filament is secured to said carrier element in a stretched configuration that is between about 125% and about 600% of its initial length.