Matrix and layer compositions for protection of bioactives

• US 9,452,143 B2
• Filed: 07/11/2013
• Issued: 09/27/2016
• Est. Priority Date: 07/12/2012
• Status: Active Grant

• Current Assignee: Novus International, Inc. (Nippon Soda Company Limited)
• Original Assignee: Novus International, Inc. (Nippon Soda Company Limited)
• Inventors: Smith, Houston Stephen, Fischer, Matthew J., Arhancet, Graciela B., Karnati, Rangarani, Hume, John A., Wang, Xiaojun
• Primary Examiner(s): TRAN, SUSAN T
• Application Number:
  US14/413,540
• Publication Number:
  US 20150157577A1
• Time in Patent Office: 1,174 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A23K 20/00 Accessory food factors for animal feeding-stuffs
• CPC Class Codes: A23K 40/30 by encapsulating; by coating
• CPC Class Codes: A23K 40/35 Making capsules specially adapted for ruminants
• CPC Class Codes: A23K 50/10 for ruminants
• CPC Class Codes: A23L 29/20 containing gelling or thickening agents marmalades, jams, jellies or other similar fruit or vegetable compositions A23L21/10
• CPC Class Codes: A23L 29/272 Gellan
• CPC Class Codes: A23L 33/10 using additives addition of substantially indigestible substances A23L33/21
• CPC Class Codes: A23L 33/12 Fatty acids or derivatives thereof
• CPC Class Codes: A23P 20/10 Coating with edible coatings, e.g. with oils or fats
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A61K 31/131 acyclic
• CPC Class Codes: A61K 31/19 Carboxylic acids, e.g. valproic acid salicylic acid A61K31/60
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 9/1617 Organic compounds, e.g. phospholipids, fats
• CPC Class Codes: A61K 9/1652 Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin homeopathic globules A61K9/1623
• CPC Class Codes: A61K 9/501 Inorganic compounds
• CPC Class Codes: A61K 9/5015 Organic compounds, e.g. fats, sugars
• CPC Class Codes: A61K 9/5026 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• CPC Class Codes: A61K 9/5031 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
• CPC Class Codes: A61K 9/5042 Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
• CPC Class Codes: A61K 9/5078 : with drug-free core

Abstract

The invention relates to matrix and layer compositions comprising a first polymer. The matrix and layer compositions are useful in the delivery of bioactives. In particular, the matrices and layers may have advantageous properties including mechanical properties and protection of bioactives and may also provide for pH-dependent release of a bioactive.

Claims

1. A composition comprising a layer formed over a core, the core comprising a bioactive agent, the layer comprising a first polymer comprising a repeat unit of Formula (I):

2. The composition of claim 1, wherein the repeat until of the first polymer comprises Formula (II):

3. The composition of claim 1, wherein Z is sulfur.

4. The composition of claim 1, wherein R⁶ is selected from the group consisting of methyl and ethyl.

5. The composition of claim 1, wherein R⁷ is not present.

6. The composition of claim 1, wherein n is an integer from 1 to 5.

7. The composition of claim 1, wherein the repeat unit of the first polymer comprises Formula (III):

8. The composition of claim 1, wherein the first polymer has an average molecular weight of at least 500 Da.

9. The composition of claim 1, wherein the bioactive agent is selected from the group consisting of essential oils, amino acids or an analogue of an amino acid, vitamins, minerals, antioxidants, pigments, enzymes, organic acids, poly unsaturated fatty acids, prebiotics, probiotics, herbs, pharmaceutically active agents, and combinations thereof.

10. The composition of claim 1, wherein the layer comprises 10% by weight of the composition.

11. The composition of claim 1, wherein the bioactive is the calcium salt of 2-hydroxy-4-methylthiobutanoic acid.

12. The composition of claim 1, wherein the composition hydrolyzes in aqueous solution at a pH below about 5.0.

13. The composition of claim 1, wherein the composition is characterized by a substantially constant release profile at a pH below about 5.0.

14. A food source comprising a nutritive source and the composition recited in claim 1.

15. A method for providing a bioactive to a subject, the method comprising administering the composition as recited in claim 1.

16. The method of claim 15, wherein the bioactive is released after passage of the composition through the rumen.