Enhancement of antimicrobial silver, silver coatings, or silver platings
First Claim
1. A method of forming an enhanced antimicrobial surface, the method comprising:
- co-depositing a coating of silver and a cathodic metal onto a substrate surface, wherein the co-deposited coating comprises a mixture of between about 25% and 75% by volume of silver, and between about 25% to 75% by volume of the cathodic metal; and
applying ozone to the coated surface for at least 5 minutes to modify the coating of the silver and the cathodic metal so that the coating is ozonated.
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Accused Products
Abstract
Antimicrobial metal ion coatings. In particular, described herein are coatings including an anodic metal (e.g., silver and/or zinc and/or copper) that is co-deposited with a cathodic metal (e.g., palladium, platinum, gold, molybdenum, titanium, iridium, osmium, niobium or rhenium) on a substrate (including, but not limited to absorbable/resorbable substrates) so that the anodic metal is galvanically released as antimicrobial ions when the apparatus is exposed to a bodily fluid. The anodic metal may be at least about 25 percent by volume of the coating, resulting in a network of anodic metal with less than 20% of the anodic metal in the coating fully encapsulated by cathodic metal.
164 Citations
30 Claims
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1. A method of forming an enhanced antimicrobial surface, the method comprising:
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co-depositing a coating of silver and a cathodic metal onto a substrate surface, wherein the co-deposited coating comprises a mixture of between about 25% and 75% by volume of silver, and between about 25% to 75% by volume of the cathodic metal; and applying ozone to the coated surface for at least 5 minutes to modify the coating of the silver and the cathodic metal so that the coating is ozonated. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method of galvanically releasing antimicrobial ions to form an antimicrobial zone around a surface of a substrate, the method comprising:
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contacting the surface with a conductive fluid, wherein the surface comprises a coating comprising a mixture of between about 25% and 75% by volume of silver, and between about 25% to 75% by volume of a cathodic metal co-deposited on the substrate, further wherein the coating has been ozonated by the application of ozone to the surface for at least 5 minutes to modify the coating of the silver and the cathodic metal so that the coating is ozonated; and galvanically releasing antimicrobial ions of the anodic metal from the coating. - View Dependent Claims (8)
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9. An apparatus that galvanically releases antimicrobial ions, the apparatus comprising:
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a substrate surface; and an ozonated coating on the outer substrate surface, the ozonated coating comprising a mixture of between about 25% and 75% by volume of silver, and between about 25% to 75% by volume of a cathodic metal co-deposited on the substrate surface, so that there is a continuous path of silver from the surface to the outer substrate surface, wherein the silver has been chemically modified by the ozone to enhance its antimicrobial activity. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. An apparatus that galvanically releases antimicrobial ions, the apparatus comprising:
a substrate surface; and
an ozonated coating on the outer substrate surface, the ozonated coating comprising a mixture of between about 25% and 75% by volume of a silver anodic metal, and between about 25% to 75% by volume of a cathodic metal co-deposited on the substrate surface, wherein the coating comprises a plurality of microregions or microdomains of the silver anodic metal in a matrix of cathodic metal or a plurality of microregions or microdomains of cathodic metal in a matrix of the silver anodic metal, the microregions or microdomains forming a continuous path of interconnected veins of the silver anodic metal through the coating thickness, or a continuous path of interconnected veins of cathodic metal through the coating thickness, wherein the continuous path extends from an outer surface of the coating through the coating to an opposite side of the coating, wherein the silver anodic metal has been chemically modified by the ozone to enhance its antimicrobial activity.- View Dependent Claims (24, 25, 26, 27, 28, 29, 30)
Specification