Method for controlling a blood component separation device including temporarily storing a component in a container

• US 9,452,254 B2
• Filed: 03/06/2015
• Issued: 09/27/2016
• Est. Priority Date: 09/11/2012
• Status: Active Grant

• Current Assignee: Terumo Kabushiki Kaisha
• Original Assignee: Terumo Kabushiki Kaisha
• Inventors: Kimura, Shigeyuki, Kobayashi, Takemi
• Primary Examiner(s): Cooley, Charles
• Assistant Examiner(s): Liu, Shuyi S
• Application Number:
  US14/640,084
• Publication Number:
  US 20150174313A1
• Time in Patent Office: 571 Days
• Field of Search: 494/37, 494/42
• US Class Current: 1/1
• CPC Class Codes: A61M 1/0218 with filters
• CPC Class Codes: A61M 1/0231 with gas separating means, e.g. air outlet through microporous membrane or gas bag
• CPC Class Codes: A61M 1/0245 combined with blood container shaking means
• CPC Class Codes: A61M 1/3693 using separation based on different densities of components, e.g. centrifuging
• CPC Class Codes: A61M 1/3696 with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
• CPC Class Codes: A61M 2202/0413 Blood
• CPC Class Codes: A61M 2202/0427 Platelets; Thrombocytes
• CPC Class Codes: B04B 11/00 Feeding, charging, or discharging bowls B04B1/00, B04B3/00, B04B7/04 take precedence
• CPC Class Codes: B04B 11/02 Continuous feeding or discharging; Control arrangements therefor

Abstract

The object of the invention is to provide a blood separation device that can reduce the total time for drawing blood to obtain high-concentration platelet liquid, thereby reducing the binding time of the blood donor. The device includes a temporary storage bag (Y2) (also serves as a buffy coat bag) which is a whole blood bag for storing whole blood drawn from a blood donor. The controlling unit of the device controls the device to draw whole blood from the blood donor in parallel with at least either a circulation flow step or an acceleration step, thereby storing the drawn whole blood in the temporary storage bag (Y2).

Claims

1. A method of controlling a blood component separation device comprising:

a centrifugal separator for separating a predetermined blood component from blood; and

a container for containing the predetermined blood component that is centrifugally separated, wherein the method comprises;

(a) a centrifugal separation step of introducing whole blood drawn from a blood donor into the centrifugal separator with a first blood pump to separate the whole blood into a plurality of blood components,

(b) a circulation flow step of introducing a predetermined first blood component, among centrifugally separated blood components, into a first container together with whole blood, and

(c) a circulation/acceleration step of stopping supply of whole blood to the centrifugal separator after separating a predetermined amount of the first blood component in the circulation flow step, introducing only the first blood component stored in the first container to the centrifugal separator with a second blood pump to circulate the first blood component for a predetermined period of time, and increasing a circulation speed in the centrifugal separator to separate and collect a second blood component,

wherein whole blood drawn from the blood donor is temporarily stored in a temporary storage container during at least a period of time in the circulation/acceleration step, and

a first tube coupled to the temporary storage container is further coupled to an outlet port of the centrifugal separator and a second tube also coupled to the temporary storage container is further coupled between the first container and the second blood pump.

2. The method according to claim 1, wherein the second tube is branched such that a first branch tube is coupled between the first container and the second blood pump and a second branch tube is coupled to an outlet port of the first blood pump,

an open/close valve is provided on each of two branch tubes branched from the second tube,

an open/close valve is provided to an outlet port of the second blood pump, and

an open/close valve is provided to an outlet port of the first container.

3. The method according to claim 2, wherein the blood component separation device is configured to perform

(d) a blood returning step, which is performed after collecting a predetermined amount of the second blood component in the circulation/acceleration step, of returning to the blood donor a blood component that is not collected, and

whole blood stored in the temporary storage container is introduced, in the centrifugal separation step in a following cycle, into the centrifugal separator together with whole blood drawn in the following cycle, the steps (a) to (d) constituting one cycle.

4. The method according to claim 3, wherein,

the circulation/acceleration step includes:

a first collecting step of transferring a portion of the second blood component with low-concentration to the temporary storage container; and

a second collecting step of collecting a portion of the second blood component with high-concentration, and

the second blood component with low-concentration transferred to the temporary storage container and whole blood collected in the temporary storage container in a following cycle are introduced into the centrifugal separator together with whole blood drawn in the following cycle.

5. The method according to claim 2, wherein, the circulation/acceleration step includes:

a first collecting step of transferring a portion of the second blood component with low-concentration to the temporary storage container; and

a second collecting step of collecting a portion of the second blood component with high-concentration, and

the second blood component with low-concentration transferred to the temporary storage container and whole blood collected in the temporary storage container in a following cycle are introduced into the centrifugal separator together with whole blood drawn in the following cycle.

6. The method according to claim 1, wherein the blood component separation device is configured to perform

(d) a blood returning step, which is performed after collecting a predetermined amount of the second blood component in the circulation/acceleration step, of returning to the blood donor a blood component that is not collected, and

whole blood stored in the temporary storage container is introduced, in the centrifugal separation step in a following cycle, into the centrifugal separator together with whole blood drawn in the following cycle, the steps (a) to (d) constituting one cycle.

7. The method according to claim 6, wherein, the circulation/acceleration step includes:

a first collecting step of transferring a portion of the second blood component with low-concentration to the temporary storage container; and

a second collecting step of collecting a portion of the second blood component with high-concentration, and

the second blood component with low-concentration transferred to the temporary storage container and whole blood collected in the temporary storage container in a following cycle are introduced into the centrifugal separator together with whole blood drawn in the following cycle.

8. The method according to claim 1, wherein the second blood pump introduces, in the centrifugal separation step in a following cycle, at least either whole blood or a low-concentration second blood component stored in the temporary storage container in a previous cycle into the centrifugal separator.

9. The method according to claim 8, wherein the second tube is branched such that a first branch tube is coupled between the first container and the second blood pump and a second branch tube is coupled to an outlet port of the first blood pump,

an open/close valve is provided on each of two branched tubes branched from the second tube,

an open/close valve is provided to an outlet port of the second blood pump, and

an open/close valve is provided to an outlet port of the first container.

10. The method according to claim 9, wherein the blood component separation device is configured to perform

(d) a blood returning step, which is performed after collecting a predetermined amount of the second blood component in the circulation/acceleration step, of returning to the blood donor a blood component that is not collected, and

whole blood stored in the storage container is introduced, in the centrifugal separation step in a following cycle, into the centrifugal separator together with whole blood drawn in the following cycle, the steps (a) to (d) constituting one cycle.

11. The method according to claim 10, wherein, the circulation/acceleration step includes:

a first collecting step of transferring a portion of the second blood component with low-concentration to the temporary storage container; and

a second collecting step of collecting a portion of the second blood component with high-concentration, and

the second blood component with low-concentration transferred to the temporary storage container and whole blood collected in the temporary storage container in a following cycle are introduced into the centrifugal separator together with whole blood drawn in the following cycle.

12. The method according to claim 9, wherein, the circulation/acceleration step includes:

a first collecting step of transferring a portion of the second blood component with low-concentration to the temporary storage container; and

a second collecting step of collecting a portion of the second blood component with high-concentration, and

the second blood component with low-concentration transferred to the temporary storage container and whole blood collected in the temporary storage container in a following cycle are introduced into the centrifugal separator together with whole blood drawn in the following cycle.

13. The method according to claim 8, wherein the blood component separation device is configured to perform

(d) a blood returning step, which is performed after collecting a predetermined amount of the second blood component in the circulation/acceleration step, of returning to the blood donor a blood component that is not collected, and

whole blood stored in the storage container is introduced, in the centrifugal separation step in a following cycle, into the centrifugal separator together with whole blood drawn in the following cycle, the steps (a) to (d) constituting one cycle.

14. The method according to claim 13, wherein, the circulation/acceleration step includes:

a first collecting step of transferring a portion of the second blood component with low-concentration to the temporary storage container; and

a second collecting step of collecting a portion of the second blood component with high-concentration, and

the second blood component with low-concentration transferred to the temporary storage container and whole blood collected in the temporary storage container in a following cycle are introduced into the centrifugal separator together with whole blood drawn in the following cycle.

15. The method according to claim 8, wherein, the circulation/acceleration step includes:

a first collecting step of transferring a portion of the second blood component with low-concentration to the temporary storage container; and

a second collecting step of collecting a portion of the second blood component with high-concentration, and

the second blood component with low-concentration transferred to the temporary storage container and whole blood collected in the temporary storage container in a following cycle are introduced into the centrifugal separator together with whole blood drawn in the following cycle.

16. The method according to claim 1, wherein, the circulation/acceleration step includes:

a first collecting step of transferring a portion of the second blood component with low-concentration to the temporary storage container; and

a second collecting step of collecting a portion of the second blood component with high-concentration, and

the second blood component with low-concentration transferred to the temporary storage container and whole blood collected in the temporary storage container in a following cycle are introduced into the centrifugal separator together with whole blood drawn in the following cycle.