Closed loop control system based on a non-invasive continuous sensor

• US 9,452,260 B2
• Filed: 11/22/2013
• Issued: 09/27/2016
• Est. Priority Date: 11/22/2013
• Status: Active Grant

• Current Assignee: Google LLC (Alphabet Inc.)
• Original Assignee: Verily Life Sciences LLC (Alphabet Inc.)
• Inventors: Yao, Huanfen
• Primary Examiner(s): VU, QUYNH-NHU HOANG
• Application Number:
  US14/088,280
• Publication Number:
  US 20150148774A1
• Time in Patent Office: 1,040 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 2010/0067 Tear or lachrymal fluid
• CPC Class Codes: A61B 2560/0214 of power generation or supply
• CPC Class Codes: A61B 2562/028 Microscale sensors, e.g. electromechanical sensors [MEMS]
• CPC Class Codes: A61B 5/002 Monitoring the patient using a local or closed circuit, e.g. in a room or building A61B5/0017 takes precedence
• CPC Class Codes: A61B 5/0022 Monitoring a patient using a global network, e.g. telephone networks, internet
• CPC Class Codes: A61B 5/14507 specially adapted for measuring characteristics of body fluids other than blood devices for taking samples of body liquids A61B10/0045
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1477 non-invasive
• CPC Class Codes: A61B 5/4836 Diagnosis combined with treatment in closed-loop systems or methods A61B5/0036 takes precedence
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/6821 Eye
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence
• CPC Class Codes: A61M 2205/3317 Electromagnetic, inductive or dielectric measuring means
• CPC Class Codes: A61M 2205/3561 local, e.g. within room or hospital
• CPC Class Codes: A61M 2205/3576 with non implanted data transmission devices, e.g. using external transmitter or receiver
• CPC Class Codes: A61M 2205/3584 using modem, internet or bluetooth
• CPC Class Codes: A61M 2205/3592 using telemetric means, e.g. radio or optical transmission
• CPC Class Codes: A61M 2205/6054 Magnetic identification systems
• CPC Class Codes: A61M 2210/0612 Eyes
• CPC Class Codes: A61M 2230/005 Parameter used as control input for the apparatus
• CPC Class Codes: A61M 2230/201 : Glucose concentration
• CPC Class Codes: A61M 5/142 : Pressure infusion, e.g. using pumps
• CPC Class Codes: A61M 5/14244 : adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/1723 : using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: G02C 7/04 : Contact lenses for the eyes disinfection or sterilisation of contact lenses A61L12/00

Abstract

Methods and systems for controlling analyte levels are described. An example method may include receiving a sensor measurement relating to an eye-mountable device. The method also may include determining an analyte concentration based on the one or more sensor measurements, and comparing the analyte concentration to a target analyte concentration. Based on the comparing, the method further may include providing instructions to a drug delivery device, where the instructions are configured to control a drug delivery rate by the drug delivery device.

Claims

1. A system comprising:

an eye-mountable device including a polymeric material;

an electrochemical sensor mounted in the eye-mountable device, wherein the electrochemical sensor provides one or more sensor measurements indicative of glucose concentration in a tear-film contacting the eye-mountable device;

a reader including one or more antennas, wherein the reader;

(i) transmits radio frequency (RF) radiation to power the eye-mountable device and the electrochemical sensor, and (ii) receives indications of the one or more sensor measurements; and

a controller in communication with the reader, wherein the controller;

(i) receives information related to the one or more sensor measurements from the reader;

(ii) obtains a target value for glucose concentration in the tear-film;

(iii) compares the glucose concentration in the tear-film to the target value for glucose concentration in the tear-film; and

(iv) based on the comparing, provides instructions to an insulin delivery device to control an insulin delivery rate to a blood stream by the insulin delivery device so as to reduce discrepancy between the glucose concentration in the tear-film and the target value for glucose concentration in the tear-film.

2. The system of claim 1, wherein the controller is integrated into:

(i) the reader, (ii) the insulin delivery device, or (iii) a remote device in communication with the reader and the insulin delivery device.

3. The system of claim 1, wherein the eye-mountable device further includes a reagent that selectively reacts with an analyte in the tear-film contacting the eye-mountable device, and wherein the reagent is localized proximate the electrochemical sensor.

4. The system of claim 1, wherein the reader transmits the RF radiation to power the eye-mountable device and the electrochemical sensor at least a predetermined period of time before receiving the indications of the one or more sensor measurements.

5. The system of claim 1, wherein the polymeric material includes a channel configured to expose the electrochemical sensor to the tear-film contacting the polymeric material of the eye-mountable device.

6. The system of claim 1, wherein the controller establishes a rate of change of glucose concentration based on the information related to the one or more sensor measurements, wherein the instructions to the insulin delivery device are further based on the established rate of change of glucose concentration.