Methods of making cell carrier
First Claim
1. A method of making a carrier for growing cells, comprising:
- a) providing a polymer film;
b) embossing on at least two sides of the polymer film with at least two embossing rollers comprising a patterned surface, wherein a first roller of the at least two rollers comprises a first plurality of protrusions, and wherein a second roller of the at least two rollers comprises a second plurality of protrusions;
c) generating a first pattern of structured indentations on a first side and second pattern of structured indentations on a second side opposing the first side of the at least two sides of the polymer film, wherein the first pattern is different than the second pattern and wherein the first roller of the at least two rollers comprises a plurality of protrusions of a first shape, and wherein the second roller of the at least two rollers comprises a plurality of protrusions of a second shape; and
d) discretizing the patterned polymer film into a plurality of portions.
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Accused Products
Abstract
A method of making a carrier for growing cells, including providing a polymer film; embossing a patterned surface one or more sides of the polymer film with an embossing roller; generating a pattern of structured indentations on the polymer film; and discretizing the patterned polymer film into a plurality of portions. The embossing pattern generates relief features on the carrier surface. An alternative method of making a carrier is also provided, including extruding a polymer film; embossing a patterned surface on the polymer film with a roller; generating a pattern of structured indentations on the polymer film; imparting a surface treatment to the film; and discretizing the treated polymer film into a plurality of portions.
68 Citations
29 Claims
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1. A method of making a carrier for growing cells, comprising:
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a) providing a polymer film; b) embossing on at least two sides of the polymer film with at least two embossing rollers comprising a patterned surface, wherein a first roller of the at least two rollers comprises a first plurality of protrusions, and wherein a second roller of the at least two rollers comprises a second plurality of protrusions; c) generating a first pattern of structured indentations on a first side and second pattern of structured indentations on a second side opposing the first side of the at least two sides of the polymer film, wherein the first pattern is different than the second pattern and wherein the first roller of the at least two rollers comprises a plurality of protrusions of a first shape, and wherein the second roller of the at least two rollers comprises a plurality of protrusions of a second shape; and d) discretizing the patterned polymer film into a plurality of portions. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method of making a carrier for growing cells, comprising:
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a) providing a polymer film; b) embossing on at least two sides of the polymer film with at least two embossing rollers comprising a patterned surface, wherein a first roller of the at least two rollers comprises a first plurality of indentations, and wherein the second roller of the at least two rollers comprises a second plurality of indentations; c) generating a first pattern of relief features on a first side and second pattern of relief features on a second side opposing the first side of the at least two sides of the polymer film, wherein the first pattern is different than the second pattern and wherein the relief features generated on the first side of the polymer film comprise protrusions of a first shape, and wherein the relief features generated on the second side of the polymer film comprise protrusions of a second shape; and d) discretizing the patterned polymer film into a plurality of portions. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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Specification