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Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response

  • US 9,453,228 B2
  • Filed: 12/01/2015
  • Issued: 09/27/2016
  • Est. Priority Date: 10/12/2005
  • Status: Active Grant
First Claim
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1. An immune regulatory oligonucleotide (IRO) compound comprising the sequence 5′

  • -CTATCTGUYZTTCTCTGT-3′

    (SEQ ID NO;

         102), wherein G is 2′

    -OMe-G and U is 2′

    -OMe-U and wherein YZ is an oligonucleotide motif that is CpG, C*pG, C*pG* or CpG* wherein C is deoxycytosine, C* is 2′

    -deoxythymidine, 1-(2′

    -deoxy-β

    -D-ribofuranosyl)-2-oxo-7-deaza-8-methyl-purine, 2′

    -dideoxy-5-halocytosine, 2′

    -dideoxy-5-nitrocytosine, arabinocytidine, 2′

    -deoxy-5-hydroxycytidine, 2′

    -deoxy-N4-alkyl-cytidine, 2′

    -deoxy-4-thiouridine, or other pyrimidine nucleoside analogs;

    G is deoxyguanosine, and G* is 2′

    -deoxy-7-deazaguanosine, 2′

    -deoxy-6-thioguanosine, arabinoguanosine, 2′

    -deoxyinosine, or other purine nucleoside analogs.

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