Devices and methods for analyzing layers of samples

• US 9,453,764 B2
• Filed: 07/21/2015
• Issued: 09/27/2016
• Est. Priority Date: 01/26/2015
• Status: Active Grant

• Current Assignee: H20ptx Inc.
• Original Assignee: H2Optx, Inc
• Inventors: Hofmeister, Rudolf J., Ice, Donald A., Tandy, Scott W.
• Primary Examiner(s): Nur, Abdullahi
• Application Number:
  US14/805,221
• Publication Number:
  US 20160216199A1
• Time in Patent Office: 434 Days
• Field of Search: 356/300, 356 72- 73
• US Class Current: 1/1
• CPC Class Codes: B01D 46/0002 Casings; Housings; Frame constructions
• CPC Class Codes: B01D 46/42 Auxiliary equipment or operation thereof
• CPC Class Codes: G01J 3/00 Spectrometry; Spectrophotometry; Monochromators; Measuring colours
• CPC Class Codes: G01J 3/0202 Mechanical elements; Supports for optical elements
• CPC Class Codes: G01J 3/0205 Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
• CPC Class Codes: G01J 3/0237 Adjustable, e.g. focussing
• CPC Class Codes: G01J 3/0267 Sample holders for colorimetry
• CPC Class Codes: G01J 3/0286 Constructional arrangements for compensating for fluctuations caused by temperature, humidity or pressure, or using cooling or temperature stabilization of parts of the device; Controlling the atmosphere inside a spectrometer, e.g. vacuum
• CPC Class Codes: G01J 3/0291 Housings; Spectrometer accessories; Spatial arrangement of elements, e.g. folded path arrangements
• CPC Class Codes: G01J 3/06 Scanning arrangements arrangements for order-selection
• CPC Class Codes: G01J 3/10 Arrangements of light sources specially adapted for spectrometry or colorimetry
• CPC Class Codes: G01J 3/2823 Imaging spectrometer
• CPC Class Codes: G01J 3/42 Absorption spectrometry; Double beam spectrometry; Flicker spectrometry; Reflection spectrometry beam switching arrangements G01J3/08
• CPC Class Codes: G01J 3/44 Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
• CPC Class Codes: G01N 1/06 providing a thin slice, e.g. microtome
• CPC Class Codes: G01N 2021/0106 General arrangement of respective parts
• CPC Class Codes: G01N 21/01 Arrangements or apparatus for facilitating the optical investigation
• CPC Class Codes: G01N 21/25 Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
• CPC Class Codes: G01N 21/253 for batch operation, i.e. multisample apparatus analytical automats G01N35/00
• CPC Class Codes: G01N 21/33 using ultraviolet light G01N21/39 takes precedence
• CPC Class Codes: G01N 21/3504 : for analysing gases, e.g. multi-gas analysis
• CPC Class Codes: G01N 21/3577 : for analysing liquids, e.g. polluted water
• CPC Class Codes: G01N 21/65 : Raman scattering
• CPC Class Codes: G01N 2201/0231 : Thermostating
• CPC Class Codes: G01N 23/00 : Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
• CPC Class Codes: G01N 33/15 : Medicinal preparations ; Physical properties thereof, e.g. dissolubility
• CPC Class Codes: G01N 35/10 : Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices G01N35/0099 takes precedence

Abstract

The present disclosure generally relates to systems, devices and methods for analyzing and processing samples or analytes. In one example configuration, a method of analyzing an analyte includes shaving a first layer of a plurality of layers of an analyte to expose a first surface of an analyte. The method includes positioning the first surface of the analyte over a window of a hyperspectral analyzation subassembly. The method further includes scanning the first surface of the analyte by the hyperspectral analyzation subassembly to obtain information regarding the analyte proximate the first surface. Other systems, devices and methods are disclosed herein.

Claims

1. A system for analyzing layers of an analyte, the system comprising:

a paring subassembly including at least one paring member sized and shaped to remove layers of an analyte to expose underlying surfaces of the analyte;

a mandrel subassembly including a mandrel defining a receptacle sized and shaped to retain the analyte as the layers of the analyte are removed;

an actuation subassembly to;

actuate the mandrel or the at least one paring member in one or more directions of movement with respect to one another to displace the analyte across the at least one paring member to remove a first layer of the analyte to expose a first surface; and

actuate the mandrel to position the exposed first surface of the analyte over a window of a hyperspectral analyzation subassembly to be scanned by the hyperspectral analyzation subassembly through the window.

2. The system of claim 1, the paring subassembly further including a housing defining a chamber to receive remnants of at least a portion of the removed first layer of the analyte.

3. The system of claim 2, the paring subassembly further including a fluid outlet in fluid communication with the chamber to evacuate the chamber.

4. The system of claim 1, wherein the at least one paring member includes at least one of:

a paring surface to remove at least a portion of the first layer by abrasion or frictional force;

or

a paring edge to remove at least the portion of the first layer.

5. The system of claim 1, the paring subassembly further including a plurality of paring members arranged along an axis parallel to a first of the one or more directions of movement.

6. The system of claim 1, the actuation subassembly comprising:

a first actuator to actuate the mandrel subassembly in a first direction of movement of the one or more directions of movement; and

a first slide movably coupling the mandrel subassembly to the first actuator to accommodate movement of the mandrel subassembly in the first direction of movement by the first actuator.

7. The system of claim 6, the actuation subassembly further comprising:

a second actuator to actuate the mandrel subassembly in a second direction of the one or more directions of movement; and

a second slide movably coupling the mandrel subassembly to the second actuator and configured to accommodate movement of the mandrel subassembly in the second direction of movement by the second actuator.

8. The system of claim 7, the hyperspectral analyzation subassembly comprising:

one or more transmitters to generate electromagnetic radiation towards the analyte;

one or more sensors to detect electromagnetic radiation from the analyte; and

an analyzation actuation subassembly to actuate at least a portion of the hyperspectral analyzation subassembly to scan the analyte.

9. The system of claim 8, the hyperspectral analyzation subassembly further comprising:

an optical multiplexer to direct electromagnetic radiation travelling between the analyte and at least one of the one or more sensors and/or the one or more transmitters; and

an objective electromagnetically coupled between the window and the optical multiplexer to focus electromagnetic radiation travelling to or from the analyte.

10. The system of claim 8, the analyzation actuation subassembly further comprising:

a third actuator to actuate at least the portion of the hyperspectral analyzation subassembly in a third direction of movement of the one or more directions of movement;

a fourth actuator to actuate at least the portion of the hyperspectral analyzation subassembly in a fourth direction of movement of the one or more directions of movement; and

a fifth actuator to actuate at least the portion of the hyperspectral analyzation subassembly in a fifth direction of movement of the one or more directions of movement.

11. The system of claim 10, further comprising a computerized subassembly configured to one or more or a combination of:

transmit power and/or control signals to the actuation subassembly to actuate the mandrel;

transmit power and/or control signals to the analyzation actuation subassembly to scan the analyte; and

receive data from the hyperspectral analyzation subassembly to obtain information regarding the analyte.

12. The system of claim 11, wherein the information regarding the analyte includes information regarding a plurality of the layers of the analyte or a plurality of the exposed surfaces of the analyte, and the computerized subassembly is configured to generate a three-dimensional representation of the information regarding the analyte including physical structure and/or chemical makeup of the analyte.

13. The system of claim 1, the mandrel subassembly further comprising:

a mandrel holder to receive the mandrel; and

a mandrel clamp to retain the mandrel in the mandrel holder in a clamped position and to permit the mandrel to be inserted into the mandrel holder or removed from the mandrel holder in an unclamped position.

14. The system of claim 1, wherein the analyte is a pharmaceutical substance of a pill form.

15. A method of analyzing a plurality of layers of an analyte comprising:

for each of the plurality of layers;

shaving the layer of the plurality of layers to expose an underlying surface of the analyte;

after shaving, positioning the exposed surface of the analyte over a window of a hyperspectral analyzation subassembly; and

after positioning the exposed surface over the window, scanning the exposed surface of the analyte by the hyperspectral analyzation subassembly to obtain information regarding the analyte proximate the exposed surface; and

generating information regarding the plurality of layers of the analyte based at least in part on the obtained information.

16. The method of claim 15, wherein the shaving further comprises:

actuating a mandrel retaining the analyte in one or more directions to position the analyte against at least one paring member; and

displacing the analyte across the at least one paring member to remove the layer of the analyte to expose the underlying surface of the analyte.

17. The method of claim 15, wherein a paring subassembly includes a housing defining a chamber that receives remnants of at least a portion of the first layer removed from the analyte, the method further comprising evacuating the chamber of at least the a portion of the first layer removed from the analyte.

18. The method of claim 15, further comprising generating a three-dimensional representation of the analyte including physical structure and/or chemical makeup of the analyte, based on the obtained information.

19. The method of claim 15, further comprising:

transmitting electromagnetic radiation from an emitter to incident the exposed surface of the analyte;

moving a portion of an analyzation subassembly in one or more directions of movement with respect to the exposed surface of the analyte to scan at least a portion of the exposed surface of the analyte;

receiving electromagnetic radiation from the exposed surface of the analyte by the analyzation subassembly through the window; and

identifying at least one characteristic of a component of the analyte proximate the exposed surface based on the electromagnetic radiation received from the exposed surface of the analyte.

20. The method of claim 15, wherein the analyte is a chemical compound of a pill form or pharmaceutical substance of a pill form.

21. A filtered blade cartridge comprising:

a filtering device comprising;

a first housing defining a first chamber and an outlet conduit fluidly coupled to the first chamber;

a filter positioned inside of the first chamber and occluding the outlet conduit, wherein the filter permits fluids to pass through to the outlet conduit and separates solids to be collected in the first chamber; and

a paring subassembly comprising two or more paring members sized and shaped to remove layers of an analyte to expose underlying surfaces of the analyte.

22. The filtered blade cartridge of claim 21, further comprising

a second housing defining a second chamber and including one or more openings positioned in between the two or more paring members, the second chamber fluidly coupled to the first chamber.

23. The filtered blade cartridge of claim 21, wherein the first housing further defines a second chamber fluidly coupled to the first chamber and the outlet conduit, the filtering device further comprising a second filter positioned inside of the second chamber and occluding the outlet conduit, wherein the second filter permits fluids to pass through to the outlet conduit and separates solids to be collected in the second chamber.