Non-resistive contact electrical systems and methods for visualizing the structure and function of objects or systems

• US 9,456,758 B2
• Filed: 06/15/2015
• Issued: 10/04/2016
• Est. Priority Date: 02/22/2012
• Status: Expired due to Fees

• Current Assignee: Rescon Ltd.
• Original Assignee: Rescon Ltd.
• Inventors: Dawson, Thomas Andrew
• Primary Examiner(s): ROZANSKI, MICHAEL T
• Application Number:
  US14/740,099
• Publication Number:
  US 20150305636A1
• Time in Patent Office: 477 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 2503/40 Animals
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/0536 Impedance imaging, e.g. by tomography
• CPC Class Codes: A61B 5/061 Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body A61B1/00158 takes precedence
• CPC Class Codes: A61B 5/062 using magnetic field
• CPC Class Codes: A61B 5/08 Detecting, measuring or recording devices for evaluating the respiratory organs A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/2415 Measuring direct current [DC] or slowly varying biopotentials
• CPC Class Codes: A61B 5/25 Bioelectric electrodes therefor
• CPC Class Codes: A61B 5/291 for electroencephalography [EEG]
• CPC Class Codes: A61B 5/296 for electromyography [EMG]
• CPC Class Codes: A61B 5/341 Vectorcardiography [VCG]
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence
• CPC Class Codes: A61B 6/12 Arrangements for detecting or locating foreign bodies
• CPC Class Codes: A61B 8/0841 for locating instruments
• CPC Class Codes: G01N 27/00 Investigating or analysing materials by the use of electric, electrochemical, or magnetic means G01N3/00 – G01N25/00 take precedence; measurement or testing of electric or magnetic variables or of electric or magnetic properties of materials G01R
• CPC Class Codes: G01N 27/60 by investigating electrostatic variables , e.g. electrographic flaw testing G01N27/007 takes precedence
• CPC Class Codes: G01N 35/00 Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor

Abstract

Methods and systems for sensing properties of an object or entity utilize non-resistive contact sensors alone or in combination with other sensors. The sensor data is utilized for detecting and visualizing properties of one or more biological or non-biological objects or entities.

Claims

1. A method comprising:

(a) positioning a plurality of non-resistive contact electric field sensors at an entity, each of the plurality of non-resistive contact electric field sensors being positioned proximate a different particular generally predetermined location;

(b) repeatedly measuring, utilizing the plurality of non-resistive contact electric field sensors, an electrical potential associated with two or more sections of an electrically active structure of the entity;

(c) accessing, from a database, data corresponding to past measurements of the electrically active structure taken utilizing non-resistive contact electric field sensors;

(d) electronically determining, by comparing data obtained from the repeated measuring to the accessed data, a current property of the electrically active structure of the entity; and

(e) generating, utilizing data obtained from the repeated measuring, a visualization of the electrically active structure of the entity of which the current property is determined, the visualization including a depiction of each of the two or more sections of the electrically active structure, together with a visualization of a typical state of the electrically active structure generated based on the accessed data.

2. The method of claim 1, wherein the method includes using one or more properties of a sensor signal to inform on the position of the structure of the entity.

3. The method of claim 1, wherein the method includes using one or more properties of a sensor signal to inform on the shape of the structure of the entity.

4. The method of claim 1, wherein the method includes using one or more properties of a sensor signal to inform on the size of the structure of the entity.

5. The method of claim 1, wherein the method comprises repeatedly repositioning the one or more non-resistive contact electric field sensors proximate the entity and determining a location of the structure of the entity based on progressive decay with distance from a source.

6. The method of claim 1, wherein the entity is an organ, and wherein the method comprises utilizing known path information to inform on the structure or function of the organ.

7. The method of claim 1, wherein the method further includes utilizing external stimulus, and synchronizing the sensors with the external stimulus.

8. The method of claim 1, wherein the method further includes utilizing external stimulus, and synchronizing the sensors with the external stimulus, repeatedly measuring the response to the external stimulus, and averaging measurement results to remove random noise.

9. The method of claim 1, wherein the method includes one or more other interrogation modalities to inform, target, calibrate, and validate an electric field visualization.

10. The method of claim 1, wherein other scanning modalities are utilized to identify electrical firing patterns.

11. The method of claim 1, wherein the method includes repositioning at least one of the plurality of sensors based on information obtained utilizing an imaging methodology.

12. The method of claim 1, wherein sensor findings are verified utilizing ultrasound when visualizing the structure of the entity.

13. The method of claim 1, wherein sensor findings are verified utilizing X-ray when visualizing the structure of the entity.

14. The method of claim 1, wherein sensor findings are tuned utilizing ultrasound when visualizing the structure of the entity.

15. The method of claim 1, wherein sensor findings are tuned utilizing X-ray when visualizing the structure of the entity.

16. The method of claim 1, wherein the structure of the entity comprises a heart, and sensor findings are validated using another sensing modality.

17. The method of claim 1, wherein the structure of the entity comprises a brain, and sensor findings are validated using another sensing modality.

18. The method of claim 1, wherein the structure of the entity comprises one or more components of the respiratory system, and sensor findings are validated using another sensing modality.

19. The method of claim 1, wherein the structure of the entity comprises a gastrointestinal tract, and sensor findings are validated using another sensing modality.

20. The method of claim 1, wherein the structure of the entity comprises one or more blood vessels, and sensor findings are validated using another sensing modality.