Swallowable drug delivery device and methods of drug delivery
First Claim
1. An ingestible device suitable for swallowing into a lumen of a gastrointestinal tract of a patient, the lumen having a lumen wall, the device comprising:
- a capsule sized to pass through the intestinal tract;
a solid therapeutic agent preparation disposed in the capsule, the solid therapeutic agent preparation shaped as a tissue penetrating member and configured to be inserted into a wall of a small intestine, the solid therapeutic agent preparation comprising at least one therapeutic agent which would chemically degrade if released within the lumen of the gastrointestinal tract; and
a release element operably coupled to the therapeutic agent preparation, the release element configured to release the solid therapeutic agent preparation from the capsule into the wall of the small intestine responsive to a condition in the small intestine, wherein when the preparation is released into the wall of the small intestine, chemical degradation of the at least one therapeutic agent in the lumen is inhibited.
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Accused Products
Abstract
Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Some embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. The device comprises a capsule sized to be swallowed and pass through the intestinal tract. The capsule can include at least one guide tube, one or more tissue penetrating members positioned in the guide tube, a delivery member, an actuating mechanism and a release element. The release element degrades upon exposure to various conditions in the intestine so as to release and actuate the actuating mechanism. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.
208 Citations
29 Claims
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1. An ingestible device suitable for swallowing into a lumen of a gastrointestinal tract of a patient, the lumen having a lumen wall, the device comprising:
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a capsule sized to pass through the intestinal tract; a solid therapeutic agent preparation disposed in the capsule, the solid therapeutic agent preparation shaped as a tissue penetrating member and configured to be inserted into a wall of a small intestine, the solid therapeutic agent preparation comprising at least one therapeutic agent which would chemically degrade if released within the lumen of the gastrointestinal tract; and a release element operably coupled to the therapeutic agent preparation, the release element configured to release the solid therapeutic agent preparation from the capsule into the wall of the small intestine responsive to a condition in the small intestine, wherein when the preparation is released into the wall of the small intestine, chemical degradation of the at least one therapeutic agent in the lumen is inhibited. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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Specification