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Compositions and methods comprising bupropion or related compounds for sustained delivery of dextromethorphan

  • US 9,457,025 B2
  • Filed: 01/15/2016
  • Issued: 10/04/2016
  • Est. Priority Date: 11/05/2013
  • Status: Active Grant
First Claim
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1. A method of increasing dextromethorphan plasma levels in a human being, comprising co-administering bupropion with about 40 mg to about 500 mg of dextromethorphan once a day or about 10 mg to about 300 mg of dextromethorphan twice a day to the human being for eight consecutive days, wherein the human being is an extensive metabolizer of dextromethorphan in need of treatment with dextromethorphan, and wherein on the eighth day that bupropion and dextromethorphan are co-administered, the co-administration results in an AUC0-12 of dextromethorphan that is at least about 20 times the AUC0-12 that would be achieved by administering the same amount of dextromethorphan without bupropion for eight consecutive days.

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