Methods for the prevention and treatment of burn injuries and secondary complications

• US 9,457,057 B2
• Filed: 10/23/2013
• Issued: 10/04/2016
• Est. Priority Date: 03/20/2009
• Status: Active Grant

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Tompkins, Ronald G., Tzika, A. Aria, Yu, Yong-Ming, Rahme, Laurence, Martyn, Jeevendra A.
• Primary Examiner(s): Alstrum Acevedo, James H
• Assistant Examiner(s): Coffa, Sergio
• Application Number:
  US14/061,370
• Publication Number:
  US 20140288012A1
• Time in Patent Office: 1,077 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61K 38/07 Tetrapeptides
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 1/02 Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 1/16 for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 17/16 Emollients or protectives, e.g. against radiation
• CPC Class Codes: A61P 21/00 Drugs for disorders of the muscular or neuromuscular system
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The disclosure relates to methods for treating a subject suffering from a burn injury or associated complications by administering to the subject an effective amount of an aromatic-cationic peptide. For example, a burn injury may be associated with distant pathophysiological effects, such as hypermetabolism, skeletal muscle dysfunction, and organ damage. The disclosure also relates to methods for protecting a subject from a burn injury by administering an effective amount of an aromatic-cationic peptide to a subject at risk of a burn injury.

Claims

1. A method for treating wound contraction in a burned tissue in a subject in need thereof, comprising administering to the subject an effective amount of a peptide having the formula D-Arg-2′

,6′

-dimethyltyrosine-Lys-Phe-NH₂.

2. The method of claim 1, wherein the wound contraction comprises the formation of subcutaneous fibrous tissue.

3. The method of claim 1, wherein the treatment comprises reducing or preventing the formation of subcutaneous fibrous tissue.

4. The method of claim 1, wherein the treatment comprises reducing or preventing fixed flexure or fixed extension of a joint.

5. The method of claim 1, wherein the peptide is administered intravenously, orally, subcutaneously, transdermally, intraperitoneally, or topically.

6. The method of claim 5, wherein the peptide is administered topically.

7. The method of claim 1, wherein the burned tissue is a sunburn or a radiation burn.

8. The method of claim 1, wherein the peptide is administered during or after the onset of wound contraction.

9. The method of claim 1, wherein the peptide is administered at a dosage of about 3 mg/kg body weight.