Systems for monitoring and applying electrical currents in an organ perfusion system
First Claim
1. An organ care system for maintaining an explanted heart at a near physiologic condition using perfusion fluid and which allows for sending electrical signals to and from the explanted heart, the system comprising:
- a heater assembly configured to heat the perfusion fluid;
a first electrode placed in an aortic bloodstream conduit and connected to the organ care system for receiving signals from the explanted heart;
a second electrode connected to the organ care system for receiving signals from the explanted heart and sending signals thereto;
a third electrode connected to the organ care system for sending signals to the explanted heart; and
a controller that;
receives a signal from at least one of the first and second electrodes and determines whether to provide pacing signals to maintain the explanted heart based on the signal received from the at least one of the first and second electrodes, andcontrols the heater assembly to maintain the heart at a temperature between 26° and
37°
C. using the perfusion fluid,wherein at least one of the second and third electrode is in a sterile environment.
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Accused Products
Abstract
Electrode systems have been developed for use in perfusion systems to measure the electrical activity of an explanted heart and to provide defibrillation energy as necessary. The perfusion systems maintain the heart in a beating state at, or near, normal physiological conditions; circulating oxygenated, nutrient enriched perfusion fluid to the heart at or near physiological temperature, pressure and flow rate. These systems include a pair of electrodes that are placed epicardially on the right atrium and left ventricle of the explanted heart, as well as an electrode placed in the aortic blood path.
232 Citations
33 Claims
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1. An organ care system for maintaining an explanted heart at a near physiologic condition using perfusion fluid and which allows for sending electrical signals to and from the explanted heart, the system comprising:
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a heater assembly configured to heat the perfusion fluid; a first electrode placed in an aortic bloodstream conduit and connected to the organ care system for receiving signals from the explanted heart; a second electrode connected to the organ care system for receiving signals from the explanted heart and sending signals thereto; a third electrode connected to the organ care system for sending signals to the explanted heart; and a controller that; receives a signal from at least one of the first and second electrodes and determines whether to provide pacing signals to maintain the explanted heart based on the signal received from the at least one of the first and second electrodes, and controls the heater assembly to maintain the heart at a temperature between 26° and
37°
C. using the perfusion fluid,wherein at least one of the second and third electrode is in a sterile environment. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. An organ care system for maintaining an explanted heart at a near physiologic condition using perfusion fluid, the system comprising:
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a heater assembly configured to heat the perfusion fluid; a first electrode connected to the organ care system for receiving signals from an explanted heart, wherein the first electrode is placed in the aortic bloodstream of the explanted heart; a second electrode connected to the organ care system for receiving signals from the explanted heart and sending signals thereto, wherein the second electrode is configured to be placed on the explanted heart adjacent the right atria; a third electrode connected to the organ care system for sending signal to the explanted heart, wherein the third electrode is configured to be placed epicardially on the explanted heart adjacent the left ventricle when the explanted heart is maintained at a near physiologic condition; and a controller that; receives a signal from at least one of the first and second electrodes and determines whether to provide pacing signals to maintain the explanted heart based on the signal received from the at least one of the first and second electrodes, and controls the heater assembly to maintain the heart at a temperature between 26° and
37°
C. using the perfusion fluid. - View Dependent Claims (12, 13, 14, 15, 16)
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17. An apparatus for maintaining an explanted heart at a near physiologic condition using perfusion fluid, the apparatus comprising:
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a heater assembly configured to heat the perfusion fluid; a first electrode placed in the aortic bloodstream of an explanted heart, wherein the first electrode is comprised of at least one of stainless steel and polycarbonate; a second electrode for epicardial placement on the explanted heart; a third electrode for epicardial placement on the explanted heart; a controller that; receives a signal from at least one of the first, second and third electrodes, and determines whether to provide pacing signals to maintain the explanted heart based on the signal received from the at least one of the first, second and third electrodes, and controls the heater assembly to maintain the heart at a temperature between 26° and
37°
C. using the perfusion fluid;wherein at least one of the second electrode and third electrode is comprised of stainless steel, wherein at least a portion of at least one of the second electrode and third electrode is covered by silicone; and wherein at least one of the first electrode, second electrode and third electrode is configured to send and receive signals to the explanted heart while the heart is at a near physiologic condition. - View Dependent Claims (18, 19, 20, 21)
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22. An organ care system for maintaining an explanted organ at a near physiologic condition, the system comprising:
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a silicone pad defining an aperture and being configured to be in contact with the explanted organ; a chamber configured to hold the explanted organ; a heater assembly configured to heat perfusion fluid; a first electrode disposed in an aortic bloodstream conduit coupled to the chamber that receives electrical signals from the explanted organ; a second electrode disposed in the chamber and that contacts the explanted organ through the aperture in the silicone pad when the explanted organ is placed in the chamber; a controller that; receives a signal from at least one of the first and second electrodes and to determines whether to provide pacing signals to maintain the explanted heart based on the signal received from the at least one of the first and second electrodes, and controls the heater assembly to maintain the explanted organ at a temperature between 26° and
37°
C. using the perfusion fluid. - View Dependent Claims (23, 24, 25, 26)
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27. An organ care system for maintaining an explanted heart at a near physiologic condition using perfusion fluid, the system comprising:
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a heater assembly configured to heat perfusion fluid; an aortic electrode connected to the organ care system placed in an aortic bloodpath of an explanted heart, wherein the aortic electrode is configured to receive electrocardiogram (ECG) signals from the explanted heart; a right atrial electrode connected to the organ care system for epicardial placement on the explanted heart, wherein the right atrial electrode is configured to receive ECG signal from the explanted heart, and wherein the right atrial electrode is configured to send to the explanted heart at least one of defibrillation energy and pacing signals; a left ventricle electrode connected to the organ care system for epicardial placement on the explanted heart, wherein the left ventricle electrode is configured to send to the explanted heart at least one of defibrillation energy and pacing signals; and a controller that; receives a signal from at least one of aortic and right atrial electrodes and determines whether to provide pacing signals to maintain the explanted heart based on the signal received from the at least one of the aortic and right atrial electrodes, and controls the heater assembly to maintain the heart at a temperature between 26° and
37°
C. using the perfusion fluid. - View Dependent Claims (28, 29)
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30. An organ care system for maintaining an explanted heart at a near physiologic condition using perfusion fluid, the system comprising:
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a circuit for receiving electrocardiogram (ECG) signals from the explanted heart, wherein the circuit comprises; a first electrode placed in the aortic bloodpath of the explanted heart; a second electrode configured to be placed epicardially on the explanted heart; a perfusion fluid configured to perfuse the explanted heart; and a heater assembly configured to heat perfusion fluid; a controller that; measures the ECG signals from the explanted heart, and determines whether to provide pacing signals to maintain the explanted heart based on at least the measured ECG signal, and controls the heater assembly to maintain the heart at a temperature between 26° and
37°
C. using the perfusion fluid. - View Dependent Claims (31)
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32. A method for measuring electrocardiogram (ECG) signals in an organ care system for maintaining an explanted heart at a near physiologic condition, the method comprising:
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maintaining the heart at a temperature between 26° and
37°
C.;placing a first electrode in the aortic bloodpath of the explanted heart; placing a second electrode epicardially on the explanted heart; measuring ECG signals produced by the explanted heart using a circuit comprising at least the first and second electrodes, a perfusion fluid, and the explanted heart; receiving signals from the circuit; and determining whether pacing signals to maintain the heart are required.
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33. A method for sending and receiving signals in an organ care system for maintaining an explanted heart at a near physiologic condition, the method comprising:
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maintaining the heart at a temperature between 26° and
37°
C.;providing a perfusion fluid to the explanted heart; providing a defibrillation source; placing at least a first electrode in the aortic bloodpath of the explanted heart; placing a second electrode epicardially; placing a third electrode epicardially; forming a second circuit comprising the second electrode, the third electrode and the defibrillation source; receiving electrocardiogram (ECG) signals from a first circuit comprising the first electrode, the second electrode, and the perfusion fluid, wherein the ECG signals are measured from the explanted heart; and sending at least one of a defibrillation signal and a pacing signal to a second circuit comprising the second electrode, the third electrode, and the defibrillation source, to maintain the heart.
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Specification