Device and method for dispensing or receiving a liquid volume

• US 9,459,128 B2
• Filed: 05/31/2013
• Issued: 10/04/2016
• Est. Priority Date: 06/01/2012
• Status: Active Grant

• Current Assignee: Albert Ludwigs University of Freiburg, Hahn-Schickard-Gesellschaft für angewandte Forschung e.V.
• Original Assignee: Albert Ludwigs University of Freiburg, Hahn-Schickard-Gesellschaft für angewandte Forschung e.V.
• Inventors: Steinert, Chris, Koltay, Peter, Ernst, Andreas, Tanguy, Laurent
• Primary Examiner(s): Shaver, Kevin P
• Assistant Examiner(s): NICHOLS II, ROBERT K
• Application Number:
  US13/907,365
• Publication Number:
  US 20130327787A1
• Time in Patent Office: 1,222 Days
• Field of Search: 222/386, 222/394, 222/61, 222/384, 222/55, 222/389, 222/386.5, 604/67
• US Class Current: 1/1
• CPC Class Codes: G01F 11/021 of the piston type G01F11/04 takes precedence
• CPC Class Codes: G01F 11/029 provided with electric controlling means G01F11/022 and G01F11/024 take precedence
• CPC Class Codes: G01F 15/02 Compensating or correcting for variations in pressure, density or temperature

Abstract

A device for dispensing or receiving a liquid volume includes a liquid reservoir having an outlet, a pressure generator which provides a compressible enclosed gas volume of a constant amount of substance with a pressure, wherein the gas volume is in direct or indirect fluidic contact with the liquid in the liquid reservoir, a dosing device coupled to the outlet of the liquid reservoir and operable in order to enable the liquid to pass the outlet, a pressure sensor arranged to measure a current pressure in the gas volume and to output an output signal indicating the current pressure in the gas volume and a controller coupled to the pressure generator, the dosing device and the pressure sensor.

Claims

1. A device for dispensing or receiving a liquid volume, comprising:

a liquid reservoir comprising an outlet;

a pressure generator which is implemented to provide a compressible gas volume enclosed in the liquid reservoir with a pressure, wherein the compressible gas volume has a constant amount of substance and the gas volume is in direct or indirect fluidic contact with the liquid in the liquid reservoir;

a doser coupled to the outlet of the liquid reservoir and configured to be operated in order to enable the liquid to pass the outlet;

a pressure sensor for measuring a pressure existing in the gas volume and for outputting an output signal indicating the current pressure in the gas volume; and

a controller coupled to the pressure generator, the doser and the pressure sensor and which is implemented to;

control the pressure generator in order to change the pressure in the gas volume until the output signal of the pressure sensor indicates a first pressure, while the doser is not operated so that it prevents liquid from passing the outlet,

operate the doser depending on the output signal of the pressure sensor in order to dispense or receive liquid through the outlet, and

while dispensing or receiving liquid through the outlet, monitor the output signal of the pressure sensor and, depending on the monitored output signal of the pressure sensor, at least temporarily terminate the operation of the doser, wherein

the pressure generator includes a syringe pump with a syringe body and a piston, and

the piston is movable by a drive to change the pressure in the gas volume relative to the syringe body.

2. The device according to claim 1, wherein the controller is implemented to terminate the operation of the doser when the monitored output signal of the pressure sensor indicates that the pressure within the gas volume has changed by a predetermined pressure difference.

3. The device according to claim 1, wherein the controller is implemented to terminate the operation of the doser when the monitored output signal of the pressure sensor over time fulfills a predetermined condition.

4. The device according to claim 1, wherein the controller is implemented, based on the output signals of the pressure sensor over time, to calculate a flow rate of a flow of the liquid through the outlet and/or an overall dispensed or received liquid volume and to terminate the operation of the doser when the flow rate and/or the overall dispensed or received liquid volume indicates the dispensing or receiving of a certain liquid volume.

5. The device according to claim 1, wherein the controller is implemented, based on the output signals of the pressure sensor, to detect the presence of an interference.

6. The device according to claim 1, wherein the piston of the syringe pump comprises a bore, wherein at least parts of the compressible gas volume are arranged within the bore.

7. The device according to claim 6, wherein the pressure sensor is in fluidic contact with the enclosed gas volume via the bore.

8. The device according to claim 1, wherein the liquid reservoir is at least partially defined by the syringe body.

9. The device according to claim 1, wherein the liquid reservoir is implemented as a member which is detachable from the pressure generator.

11. The device according to claim 1, comprising a flexible membrane fluidically separating the liquid to be dispensed from the compressible gas volume.

12. The device according to claim 1, wherein the doser is implemented as a micropump, a peristaltic pump, a dosing valve or a pinch valve.

13. The device according to claim 1, wherein the doser comprises a flexible tube and a displacer by which the volume of a section of the flexible tube is changeable in order to dispense liquid to be dispensed as free-flowing droplets or as a free-flowing jet.

10. A device for dispensing or receiving a liquid volume, comprising:

a liquid reservoir comprising an outlet;

a pressure generator which is implemented to provide a compressible gas volume enclosed in the liquid reservoir with a pressure, wherein the compressible as volume has a constant amount of substance and the gas volume is in direct or indirect fluidic contact with the liquid in the liquid reservoir;

a doser coupled to the outlet of the liquid reservoir and configured to be operated in order to enable the liquid to pass the outlet;

a pressure sensor for measuring a pressure existing in the gas volume and for outputting an output signal indicating the current pressure in the gas volume; and

a controller coupled to the pressure generator, the doser and the pressure sensor and which is implemented to;

control the pressure generator in order to change the pressure in the gas volume until the output signal of the pressure sensor indicates a first pressure, while the doser is not operated so that it prevents liquid from passing the outlet,

operate the doser depending on the output signal of the pressure sensor in order to dispense or receive liquid through the outlet, and

while dispensing or receiving liquid through the outlet, monitor the output signal of the pressure sensor and, depending on the monitored output signal of the pressure sensor, at least temporarily terminate the operation of the doser, wherein

the liquid reservoir is implemented as a member which is detachable from the pressure generator, and

the liquid reservoir is implemented as a pipette tip mountable to the pressure generator.

14. A device for dispensing or receiving a liquid volume, comprising:

a liquid reservoir comprising an outlet;

a pressure generator which is implemented to provide a compressible gas volume enclosed in the liquid reservoir with a pressure, wherein the compressible gas volume has a constant amount of substance and the gas volume is in direct or indirect fluidic contact with the liquid in the liquid reservoir;

a doser coupled to the outlet of the liquid reservoir and configured to be operated in order to enable the liquid to pass the outlet;

a pressure sensor for measuring a pressure existing in the gas volume and for outputting an output signal indicating the current pressure in the gas volume; and

a controller coupled to the pressure generator, the doser and the pressure sensor and which is implemented to;

control the pressure generator in order to change the pressure in the gas volume until the output signal of the pressure sensor indicates a first pressure, while the doser is not operated so that it prevents liquid from passing the outlet,

operate the doser depending on the output signal of the pressure sensor in order to dispense or receive liquid through the outlet, and

while dispensing or receiving liquid through the outlet, monitor the output signal of the pressure sensor and, depending on the monitored output signal of the pressure sensor, at least temporarily terminate the operation of the doser, wherein

the controller is implemented, after the at least temporary termination of the operation of the doser, to operate the doser at least once again and to terminate this renewed operation depending on the output signal of the pressure sensor so that several partial volumes of the liquid are dispensed or received from the outlet iteratively.

15. The device according to claim 14, wherein the controller is implemented, with an iterative discharge of a further partial volume, with respect to the operation of the doser, to consider data which were gained when dispensing or receiving a previous partial volume.