Systems and methods for generating and using projector curve sets for universal calibration for noninvasive blood glucose and other measurements
First Claim
1. A method for calibrating a measurement system for non-invasive analyte measurement, the method comprising the steps of:
- obtaining in memory in communication with a processor, from a selected plurality of synthetic medium samples, each having a reference analyte concentration, a plurality of energy-value sets from the measurement system, each energy value in a particular energy-value set corresponding to a respective reference analyte concentration from the selected plurality of synthetic medium samples;
generating by the processor a composite projector curve using the plurality of energy value sets and the plurality of reference analyte concentrations; and
partitioning by the processor the composite projector curve into a set of non-overlapping individual projector curves according to a set of slopes of the composite projector curve, each individual projector curve being identified by a lower bound analyte concentration and an upper bound analyte concentration.
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Accused Products
Abstract
A synthetic projection system determines analyte concentration, such as blood glucose concentration, from a spectral-energy change associated with an uncharacterized instance of a medium in which the analyte is likely present. The projection system is factory calibrated for different instances of the medium, without needing instance-specific training or calibration. The projection system includes a set of projector curves, each relating spectral-energy change values obtained by analyzing reference medium samples to analyte concentrations in those samples. Each projector curve also corresponds to a respective range of energy-change gradients, determined using a group of surrogate media characterized according to analyte concentrations measured using a reference system. A spectral-energy-change gradient for the uncharacterized medium may be computed to select one of the projectors curves. Analyte concentration in the uncharacterized medium can be reliably computed at a specified high level of accuracy using the spectral-energy change associated therewith and the selected curve.
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Citations
18 Claims
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1. A method for calibrating a measurement system for non-invasive analyte measurement, the method comprising the steps of:
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obtaining in memory in communication with a processor, from a selected plurality of synthetic medium samples, each having a reference analyte concentration, a plurality of energy-value sets from the measurement system, each energy value in a particular energy-value set corresponding to a respective reference analyte concentration from the selected plurality of synthetic medium samples; generating by the processor a composite projector curve using the plurality of energy value sets and the plurality of reference analyte concentrations; and partitioning by the processor the composite projector curve into a set of non-overlapping individual projector curves according to a set of slopes of the composite projector curve, each individual projector curve being identified by a lower bound analyte concentration and an upper bound analyte concentration. - View Dependent Claims (2, 3, 4, 5)
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6. A method for computing analyte concentration in a medium, the method comprising:
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selecting by a processor a member of a projector curve set, stored in memory in communication with the processor, according to a normalized absorption gradient (NAG) value, such that the NAG value is within a range of minimum and maximum NAG values associated with that member; and interpolating analyte concentration by the processor using a slope and an intercept of the selected member. - View Dependent Claims (7, 8, 9)
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10. A system for calibrating a measurement system for non-invasive analyte measurement, the system comprising:
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a first processor; and a first memory in electrical communication with the first processor, the first memory comprising instructions which, when executed by a processing unit comprising at least one of the first processor and a second processor, and in electronic communication with a memory module comprising at least one of the first memory and a second memory, program the processing unit to; obtain from a selected plurality of synthetic medium samples, each having a reference analyte concentration, a plurality of energy-value sets from the measurement system, each energy value in a particular energy-value set corresponding to a respective reference analyte concentration from the selected plurality of synthetic medium samples; generate a composite projector curve using the plurality of energy value sets and the plurality of reference analyte concentrations; and partition the composite projector curve into a set of non-overlapping individual projector curves according to a set of slopes of the composite projector curve, each individual projector curve being identified by a lower bound analyte concentration and an upper bound analyte concentration. - View Dependent Claims (11, 12, 13, 14)
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15. A system of computing analyte concentration in a medium, the system comprising:
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a first processor; and a first memory in electrical communication with the first processor, the first memory comprising instructions which, when executed by a processing unit comprising at least one of the first processor and a second processor, and in electronic communication with a memory module comprising at least one of the first memory and a second memory, program the processing unit to; select a member of a projector curve set according to a normalized absorption gradient (NAG) value, such that the NAG value is within a range of minimum and maximum NAG values associated with that member; and interpolate analyte concentration using a slope and an intercept of the selected member. - View Dependent Claims (16, 17, 18)
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Specification