Device for predicting non-linear, time-dependent responses of a component of a system to an input into the system
First Claim
1. A non-compartmental method of predicting a non-linear, time-dependent response of a component of a system to an input into the system, the method comprising:
- identifying the system, the component, the input, and the non-linear, time-dependent response;
wherein, the input includes a set of actual inputs and a test input, and the non-linear time-dependent response includes a set of non-linear, time-dependent actual responses and a non-linear, test response;
obtaining the set of non-linear, time-dependent actual responses of the component to the set of actual inputs;
using the set of actual inputs and the set of non-linear, time-dependent actual responses to provide a model for predicting the non-linear, test response to the test input, the model comprising the formula
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Abstract
Non-mechanistic, differential-equation-free approaches for predicting a particular non-linear, response of a system to a given input are provided in the form of systems, methods, and devices. These approaches are generally directed to a non-compartmental method of predicting a non-linear, time-dependent response of a component of a system to an input into the system. The systems, methods, and devices provide the ability to (i) reduce the cost of research and development by offering an accurate modeling of heterogeneous and complex physical systems; (ii) reduce the cost of creating such systems and methods by simplifying the modeling process; (iii) accurately capture and model inherent nonlinearities in cases where sufficient knowledge does not exist to a priori build a model and its parameters; and, (iv) provide one-to-one relationships between model parameters and model outputs, addressing the problem of the ambiguities inherent in the current, state-of-the-art systems and methods.
18 Citations
30 Claims
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1. A non-compartmental method of predicting a non-linear, time-dependent response of a component of a system to an input into the system, the method comprising:
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identifying the system, the component, the input, and the non-linear, time-dependent response; wherein, the input includes a set of actual inputs and a test input, and the non-linear time-dependent response includes a set of non-linear, time-dependent actual responses and a non-linear, test response; obtaining the set of non-linear, time-dependent actual responses of the component to the set of actual inputs; using the set of actual inputs and the set of non-linear, time-dependent actual responses to provide a model for predicting the non-linear, test response to the test input, the model comprising the formula - View Dependent Claims (2, 3, 4, 5, 6)
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7. A non-compartmental method of predicting a non-linear, time-dependent response of a component of a mammalian system to an input into the system, the method comprising:
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selecting a component of the system, the component selected from the group consisting of a cell, a tissue, an organ, a DNA, a virus, a protein, an antibody, a bacteria; selecting a set of actual inputs, the set of actual inputs having an element selected from the group consisting of a DNA, a virus, a protein, an antibody, a bacteria, a chemical, a dietary supplement, a nutrient, and a drug; obtaining a set of non-linear, time-dependent actual responses of the component to the set of actual inputs; using the set of actual inputs and the set of non-linear, time-dependent actual responses to provide a model for predicting a non-linear, test response to a test input, the model comprising the formula - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A device for predicting a non-linear, time-dependent response of a component of a physical system to an input into the system, the device comprising:
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a processor; a database for storing a set of actual input data, a set of non-linear, time-dependent actual response data, test input data, and non-linear, time-dependent test response data on a non-transitory computer readable medium; an enumeration engine on a non-transitory computer readable medium to parameterize a non-compartmental model for predicting a non-linear, test response to a test input, the non-compartmental model comprising the formula - View Dependent Claims (20)
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21. A device for predicting a non-linear, time-dependent response of a component of a mammalian system to an input into the system, the device comprising:
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a processor; a database for storing a set of actual input data, a set of non-linear, time-dependent actual response data, test input data, and non-linear, time-dependent test response data on a non-transitory computer readable medium; an enumeration engine on a non-transitory computer readable medium to parameterize a non-compartmental model for predicting a non-linear, test response to a test input, the non-compartmental model comprising the formula - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30)
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Specification